Roles, functions, and mechanisms of long non-coding RNAs in cancer

Y Fang, MJ Fullwood - Genomics, Proteomics and …, 2016 - academic.oup.com
Long non-coding RNAs (lncRNAs) play important roles in cancer. They are involved in
chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through …

The functions and unique features of LncRNAs in cancer development and tumorigenesis

K Taniue, N Akimitsu - International journal of molecular sciences, 2021 - mdpi.com
Over the past decades, research on cancer biology has focused on the involvement of
protein-coding genes in cancer development. Long noncoding RNAs (lncRNAs), which are …

Technological developments in lncRNA biology

S Jathar, V Kumar, J Srivastava, V Tripathi - Long Non Coding RNA …, 2017 - Springer
It is estimated that more than 90% of the mammalian genome is transcribed as non-coding
RNAs. Recent evidences have established that these non-coding transcripts are not junk or …

Long non-coding RNAs (lncRNAs) in spermatogenesis and male infertility

M Joshi, S Rajender - Reproductive Biology and Endocrinology, 2020 - Springer
Abstract Background Long non-coding RNAs (lncRNAs) have a size of more than 200 bp
and are known to regulate a host of crucial cellular processes like proliferation …

Long noncoding RNA (lincRNA), a new paradigm in gene expression control

E Deniz, B Erman - Functional & integrative genomics, 2017 - Springer
Long intergenic non-coding RNAs (lincRNAs) are defined as RNA transcripts that are longer
than 200 nucleotides. By definition, these RNAs must not have open reading frames that …

[HTML][HTML] LncRNA HOTAIR is a prognostic biomarker for the proliferation and chemoresistance of colorectal cancer via MiR-203a-3p-mediated Wnt/ss-catenin signaling …

Z Xiao, Z Qu, Z Chen, Z Fang, K Zhou… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: HOX transcript antisense RNA (HOTAIR) plays a vital role in
carcinogenesis. However, its functional and regulatory roles remain unclear. In this study …

Advances in long noncoding RNAs: identification, structure prediction and function annotation

X Guo, L Gao, Y Wang, DKY Chiu… - Briefings in functional …, 2016 - academic.oup.com
Long noncoding RNAs (lncRNAs), generally longer than 200 nucleotides and with poor
protein coding potential, are usually considered collectively as a heterogeneous class of …

Long noncoding RNA: a crosslink in biological regulatory network

Y Zhang, Y Tao, Q Liao - Briefings in bioinformatics, 2018 - academic.oup.com
Long noncoding RNAs (lncRNAs) had been defined as a novel class of functional RNAs
longer than 200 nucleotides around a decade ago. It is widely acknowledged that lncRNAs …

Non-coding RNAs: long non-coding RNAs and microRNAs in endocrine-related cancers

CM Klinge - Endocrine-related cancer, 2018 - erc.bioscientifica.com
The human genome is 'pervasively transcribed'leading to a complex array of non-coding
RNAs (ncRNAs) that far outnumber coding mRNAs. ncRNAs have regulatory roles in …

lncRNAKB, a knowledgebase of tissue-specific functional annotation and trait association of long noncoding RNA

F Seifuddin, K Singh, A Suresh, JT Judy, YC Chen… - Scientific Data, 2020 - nature.com
Long non-coding RNA Knowledgebase (lncRNAKB) is an integrated resource for exploring
lncRNA biology in the context of tissue-specificity and disease association. A systematic …