The past decade has witnessed an explosion in the use of super-resolution fluorescence
microscopy methods in biology and other fields. Single-molecule localization microscopy …

Optical microscopes are an important imaging tool that have effectively advanced the
development of modern biomedicine. In recent years, super-resolution microscopy (SRM) …

INTRODUCTION In human cells, 2 m of DNA are compacted in the nucleus through
assembly with histones and other proteins into chromatin structures, megabase three …

Nucleosomes help structure chromosomes by compacting DNA into fibers. To gain insight
into how nucleosomes are arranged in vivo, we combined quantitative super-resolution …

Anyone who has used a light microscope has wished that its resolution could be a little
better. Now, after centuries of gradual improvements, fluorescence microscopy has made a …

Our understanding of the structure and function of mitotic chromosomes has come a long
way since these iconic objects were first recognized more than 140 years ago, though many …

We survey the history of resolution enhancement techniques in microscopy and their impact
on current research in biomedicine. Often these techniques are labeled superresolution, or …

How is a long strand of genomic DNA packaged into a mitotic chromosome or nucleus? The
nucleosome fiber (beads-on-a-string), in which DNA is wrapped around core histones, has …

Despite over 30years of work, the fundamental structure of eukaryotic chromatin remains
controversial. Here, we review the roots of this controversy in disparities between results …

Super-resolution microscopy (SRM) technology that breaks the diffraction limit has
revolutionized the field of cell biology since its appearance, which enables researchers to …