Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …

Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that presents with rapidly
developing, painful skin ulcers hallmarked by undermined borders and peripheral erythema …

The complement system is deeply embedded in our physiology and immunity. Complement
activation generates a multitude of molecules that converge simultaneously on the …

Most patients with cholangiocarcinoma (CCA) develop extrahepatic malignant biliary
obstructions, which require palliative drainage to normalize bilirubin levels and to improve …

Vascular pathologies underpin and intertwine autoimmune rheumatic diseases and
cardiovascular conditions, and atherosclerosis is increasingly recognized as the leading …

Human neutrophils, the most abundant circulating leukocytes, are fundamental components
of the host response against different pathogens. Until a few years ago, neutrophils received …

G‐protein–coupled receptor (GPCR) signaling is essential for the spatiotemporal control of
leukocyte dynamics during immune responses. For efficient navigation through mammalian …

Cancer is highly infiltrated by myeloid-derived suppressor cells (MDSCs). Currently
available immunotherapies do not completely eradicate MDSCs. Through a genome-wide …

Eicosanoids are lipid-based signaling molecules that play a unique role in innate immune
responses. The multiple types of eicosanoids, such as prostaglandins (PGs) and …

Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis. A third of
psoriatic patients develop PsA via unknown mechanisms. No reliable diagnostic markers …