The current Coronavirus disease 2019 or COVID-19 pandemic has infected over two million
people and resulted in the death of over one hundred thousand people at the time of writing …

Major advances have occurred in recent years in our understanding of HIV-1 assembly,
release and maturation, as work in this field has been propelled forwards by developments …

Lipids play numerous indispensable cellular functions and are involved in multiple steps in
the replication cycle of viruses. Infections by human-pathogenic coronaviruses result in …

A defining property of retroviruses is their ability to assemble into particles that can leave
producer cells and spread infection to susceptible cells and hosts. Virion morphogenesis …

Three-dimensional molecular structures can provide detailed information on biological
mechanisms and, for cases in which the molecular function affects human health, can …

The HIV-1 envelope (Env) glycoproteins play an essential role in the virus replication cycle
by mediating the fusion between viral and cellular membranes during the entry process. The …

The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large
number of genetic studies and by many human diseases that involve the disruption of lipid …

Viruses have evolved complex and dynamic interactions with their host cell. In recent years
we have gained insight into the expanding roles for host lipids in the virus life cycle. In …

During the late phase of HIV type 1 (HIV-1) replication, newly synthesized retroviral Gag
proteins are targeted to the plasma membrane of most hematopoietic cell types, where they …

HIV assembly and replication proceed through the formation of morphologically distinct
immature and mature viral capsids that are organized by the Gag polyprotein (immature) …