Targeting tumor-stromal interactions in pancreatic cancer: impact of collagens and mechanical traits
P Maneshi, J Mason, M Dongre… - Frontiers in Cell and …, 2021 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC) has one of the worst outcomes among cancers
with a 5-years survival rate of below 10%. This is a result of late diagnosis and the lack of …
with a 5-years survival rate of below 10%. This is a result of late diagnosis and the lack of …
Advances in bioengineering pancreatic tumor-stroma physiomimetic Biomodels
Pancreatic cancer exhibits a unique bioarchitecture and desmoplastic cancer-stoma
interplay that governs disease progression, multi-resistance, and metastasis. Emulating the …
interplay that governs disease progression, multi-resistance, and metastasis. Emulating the …
Dynamic magneto-softening of 3D hydrogel reverses malignant transformation of cancer cells and enhances drug efficacy
High extracellular matrix stiffness is a prominent feature of malignant tumors associated with
poor clinical prognosis. To elucidate mechanistic connections between increased matrix …
poor clinical prognosis. To elucidate mechanistic connections between increased matrix …
Pancreatic Ductal Adenocarcinoma: Preclinical in vitro and ex vivo Models
B Gündel, X Liu, M Löhr, R Heuchel - Frontiers in cell and …, 2021 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC) is one of the most overlooked cancers despite its
dismal median survival time of 6 months. The biggest challenges in improving patient …
dismal median survival time of 6 months. The biggest challenges in improving patient …
Synthetic living materials in cancer biology
Living materials, which are made either of or by living cells, or are synthetic materials with
programmable elements catered to cells, are environmentally responsive and can self …
programmable elements catered to cells, are environmentally responsive and can self …
Dual functionalization of gelatin for orthogonal and dynamic hydrogel cross-linking
Gelatin-based hydrogels are widely used in biomedical fields because of their abundance of
bioactive motifs that support cell adhesion and matrix remodeling. Although inherently …
bioactive motifs that support cell adhesion and matrix remodeling. Although inherently …
Patterned photocrosslinking to establish stiffness anisotropies in fibrous 3D hydrogels
Cells are known to constantly interact with their local extracellular matrix (ECM) and respond
to a variety of biochemical and mechanical cues received from the ECM. Nonetheless …
to a variety of biochemical and mechanical cues received from the ECM. Nonetheless …
Hydrogels for salivary gland tissue engineering
Mimicking the complex architecture of salivary glands (SGs) outside their native niche is
challenging due their multicellular and highly branched organization. However, significant …
challenging due their multicellular and highly branched organization. However, significant …
[HTML][HTML] Unravelling the complexities of resistance mechanism in pancreatic cancer: insights from in vitro and ex-vivo model systems
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor prognosis and
rising global deaths. Late diagnosis, due to absent early symptoms and biomarkers, limits …
rising global deaths. Late diagnosis, due to absent early symptoms and biomarkers, limits …
Matrix stiffness regulates the protein profile of extracellular vesicles of pancreatic cancer cell lines
B Ferrara, S Bourgoin‐Voillard, D Habert, B Vallée… - …, 2024 - Wiley Online Library
The fibrotic stroma characterizing pancreatic ductal adenocarcinoma (PDAC) derives from a
progressive tissue rigidification, which induces epithelial mesenchymal transition and …
progressive tissue rigidification, which induces epithelial mesenchymal transition and …