[HTML][HTML] Extracellular vesicle-based drug delivery systems for cancer treatment

S Walker, S Busatto, A Pham, M Tian, A Suh… - Theranostics, 2019 - ncbi.nlm.nih.gov
Extracellular vesicles (EVs) are naturally occurring cell-secreted nanoparticles that play
important roles in many physiological and pathological processes. EVs enable intercellular …

Clinical cancer nanomedicine

J Wolfram, M Ferrari - Nano today, 2019 - Elsevier
Nanotechnology offers new solutions for the development of cancer therapeutics that display
improved efficacy and safety. Although several nanotherapeutics have received clinical …

Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release

N Kamaly, B Yameen, J Wu, OC Farokhzad - Chemical reviews, 2016 - ACS Publications
The development of biodegradable polymers represents a revolution in medicine spanning
over 50 years and leading to significant biotechnological advancements in drug delivery …

Application of light scattering techniques to nanoparticle characterization and development

PM Carvalho, MR Felício, NC Santos… - Frontiers in …, 2018 - frontiersin.org
Over the years, the scientific importance of nanoparticles for biomedical applications has
increased. The high stability and biocompatibility, together with the low toxicity of the …

The impact of nanoparticle protein corona on cytotoxicity, immunotoxicity and target drug delivery

C Corbo, R Molinaro, A Parodi… - …, 2016 - Taylor & Francis
In a perfect sequence of events, nanoparticles (NPs) are injected into the bloodstream
where they circulate until they reach the target tissue. The ligand on the NP surface …

The importance of apparent pKa in the development of nanoparticles encapsulating siRNA and mRNA

P Patel, NM Ibrahim, K Cheng - Trends in pharmacological sciences, 2021 - cell.com
Polymer and lipid nanoparticles have been extensively used as carriers to address the
biological barriers encountered in siRNA and mRNA delivery. We summarize the crucial role …

Safety of nanoparticles in medicine

J Wolfram, M Zhu, Y Yang, J Shen, E Gentile… - Current drug …, 2015 - ingentaconnect.com
Nanomedicine involves the use of nanoparticles for therapeutic and diagnostic purposes.
During the past two decades, a growing number of nanomedicines have received regulatory …

Photodynamic therapy with nanoparticles to combat microbial infection and resistance

A Bekmukhametova, H Ruprai, JM Hook, D Mawad… - Nanoscale, 2020 - pubs.rsc.org
Infections caused by drug-resistant pathogens are rapidly increasing in incidence and pose
an urgent global health concern. New treatments are needed to address this critical situation …

The nano-plasma interface: Implications of the protein corona

J Wolfram, Y Yang, J Shen, A Moten, C Chen… - Colloids and Surfaces B …, 2014 - Elsevier
The interactions between nanoparticles and macromolecules in the blood plasma dictate the
biocompatibility and efficacy of nanotherapeutics. Accordingly, the properties of …

Chitosan-based nanoparticles for nucleic acid delivery: technological aspects, applications, and future perspectives

M Karayianni, T Sentoukas, A Skandalis, N Pippa… - Pharmaceutics, 2023 - mdpi.com
Chitosan is a naturally occurring polymer derived from the deacetylation of chitin, which is
an abundant carbohydrate found mainly in the shells of various marine and terrestrial …