Named after the Sanskrit word netr, which means' one who guides', the netrin family of
secreted proteins provides migrational cues in the developing central nervous system …

Netrins are a family of proteins that direct cell and axon migration during development.
Three secreted netrins (netrin-1,-3 and-4) have been identified in mammals, in addition to …

Cell migration plays important roles in embryonic development and inflammation, and this
process is highly regulated to ensure tissue homeostasis. A number of barriers exist to …

Netrins, axon guidance cues in the CNS, have also been detected in epithelial tissues. In
this study, using the embryonic pancreas as a model system, we show that Netrin-1 is …

The development of many organs, including the lung, depends upon a process known as
branching morphogenesis, in which a simple epithelial bud gives rise to a complex tree-like …

Background Netrin-1 may promote colorectal and breast tumorigenesis, by inhibiting
apoptosis induced by its dependence receptors, deleted in colorectal cancer (DCC) and …

Endogenous mechanisms exist to limit inflammation. One such molecule is netrin. This study
examined the impact of ischemia-reperfusion (I/R) on netrin expression and the role of netrin …

Background Glioblastoma cells assemble to a syncytial communicating network based on
tumor microtubes (TMs) as ultra-long membrane protrusions. The relationship between …

Vertebrate laminins and netrins share N-terminal domain structure, but appear to be only
distantly related. Both families can be divided into different subfamilies on the basis of …

Airway branching morphogenesis depends on the intricate orchestration of numerous
biological and physical factors connected across different spatial scales. One of the key …