Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine

CA Brandsma, M Van den Berge… - The Journal of …, 2020 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high
personal and societal burden. Exposure to toxic particles and gases, including cigarette …

The regulatory roles of small leucine‐rich proteoglycans in extracellular matrix assembly

S Chen, DE Birk - The FEBS journal, 2013 - Wiley Online Library
Small leucine‐rich proteoglycans (SLRP s) are involved in a variety of biological and
pathological processes. This review focuses on their regulatory roles in matrix assembly …

Fractal-like hierarchical organization of bone begins at the nanoscale

N Reznikov, M Bilton, L Lari, MM Stevens, R Kröger - Science, 2018 - science.org
INTRODUCTION The components of bone assemble hierarchically to provide stiffness and
toughness. Deciphering the specific organization and relationship between bone's principal …

[HTML][HTML] Influence of cross-link structure, density and mechanical properties in the mesoscale deformation mechanisms of collagen fibrils

B Depalle, Z Qin, SJ Shefelbine, MJ Buehler - Journal of the mechanical …, 2015 - Elsevier
Collagen is a ubiquitous protein with remarkable mechanical properties. It is highly elastic,
shows large fracture strength and enables substantial energy dissipation during …

A dentin-derived hydrogel bioink for 3D bioprinting of cell laden scaffolds for regenerative dentistry

A Athirasala, A Tahayeri, G Thrivikraman… - …, 2018 - iopscience.iop.org
Recent studies in tissue engineering have adopted extracellular matrix (ECM) derived
scaffolds as natural and cytocompatible microenvironments for tissue regeneration. The …

The role of small leucine-rich proteoglycans in collagen fibrillogenesis

S Kalamajski, Å Oldberg - Matrix biology, 2010 - Elsevier
Small leucine-rich proteoglycans/proteins (SLRPs) are associated with collagen fibril
formation, and therefore important for the proper formation of extracellular matrices. SLRPs …

Fibrillar collagens

J Bella, DJS Hulmes - Fibrous proteins: structures and mechanisms, 2017 - Springer
Fibrillar collagens (types I, II, III, V, XI, XXIV and XXVII) constitute a sub-group within the
collagen family (of which there are 28 types in humans) whose functions are to provide three …

Biomimetic and Multifunctional Hemostatic Hydrogel with Rapid Thermoresponsive Gelation and Robust Wet Adhesion for Emergency Hemostasis: A Rational Design …

H Song, L Xing, W Liu, X Wang, Z Hou… - …, 2023 - ACS Publications
Uncontrolled bleeding in emergency situations is a great threat to both military and civilian
lives, and an ideal hemostat for effectively controlling prehospital hemorrhage is urgently …

[HTML][HTML] The dentin organic matrix–limitations of restorative dentistry hidden on the nanometer scale

LE Bertassoni, JPR Orgel, O Antipova, MV Swain - Acta biomaterialia, 2012 - Elsevier
The prevention and treatment of dental caries are major challenges occurring in dentistry.
The foundations for modern management of this dental disease, estimated to affect 90% of …

Lysyl oxidase activity is required for ordered collagen fibrillogenesis by tendon cells

A Herchenhan, F Uhlenbrock, P Eliasson… - Journal of Biological …, 2015 - ASBMB
Lysyl oxidases (LOXs) are a family of copper-dependent oxido-deaminases that can modify
the side chain of lysyl residues in collagen and elastin, thereby leading to the spontaneous …