Unraveling the complexity of human brain: Structure, function in healthy and disease states

OF Sultana, M Bandaru, MA Islam, PH Reddy - Ageing Research Reviews, 2024 - Elsevier
The human brain stands as an intricate organ, embodying a nexus of structure, function,
development, and diversity. This review delves into the multifaceted landscape of the brain …

Unlocking neural function with 3D in vitro models: A technical review of self-assembled, guided, and bioprinted brain organoids and their applications in the study of …

C D'Antoni, L Mautone, C Sanchini, L Tondo… - International Journal of …, 2023 - mdpi.com
Understanding the complexities of the human brain and its associated disorders poses a
significant challenge in neuroscience. Traditional research methods have limitations in …

Isolation and characterization of resident endogenous c-Kit+ cardiac stem cells from the adult mouse and rat heart

AJ Smith, FC Lewis, I Aquila, CD Waring, A Nocera… - Nature protocols, 2014 - nature.com
This protocol describes the isolation of endogenous c-Kit (also known as CD117)-positive (c-
Kit+), CD45-negative (CD45−) cardiac stem cells (eCSCs) from whole adult mouse and rat …

Traumatic brain injury activation of the adult subventricular zone neurogenic niche

EH Chang, I Adorjan, MV Mundim, B Sun… - Frontiers in …, 2016 - frontiersin.org
Traumatic brain injury (TBI) is common in both civilian and military life, placing a large
burden on survivors and society. However, with the recognition of neural stem cells in adult …

The effects of extrinsic and intrinsic factors on neurogenesis

M Jiang, SE Jang, L Zeng - Cells, 2023 - mdpi.com
In the mammalian brain, neurogenesis is maintained throughout adulthood primarily in two
typical niches, the subgranular zone (SGZ) of the dentate gyrus and the subventricular zone …

The protective effect of melatonin on neural stem cell against LPS‐induced inflammation

J Song, SM Kang, KM Lee… - BioMed research …, 2015 - Wiley Online Library
Stem cell therapy for tissue regeneration has several limitations in the fact that transplanted
cells could not survive for a long time. For solving these limitations, many studies have …

Clozapine protects adult neural stem cells from ketamine-induced cell death in correlation with decreased apoptosis and autophagy

M Lundberg, S Curbo, H Bohman, I Agartz… - Bioscience …, 2020 - portlandpress.com
Adult neurogenesis, the production of newborn neurons from neural stem cells (NSCs) has
been suggested to be decreased in patients with schizophrenia. A similar finding was …

Klotho regulates postnatal neurogenesis and protects against age-related spatial memory loss

AM Laszczyk, S Fox-Quick, HT Vo, D Nettles… - Neurobiology of …, 2017 - Elsevier
Although the absence of the age-regulating klotho protein causes klotho-deficient mice to
rapidly develop cognitive impairment and increasing klotho enhances hippocampal …

NFL-lipid nanocapsules for brain neural stem cell targeting in vitro and in vivo

D Carradori, P Saulnier, V Préat, A Des Rieux… - Journal of Controlled …, 2016 - Elsevier
The replacement of injured neurons by the selective stimulation of neural stem cells in situ
represents a potential therapeutic strategy for the treatment of neurodegenerative diseases …

Neurospheres: a potential in vitro model for the study of central nervous system disorders

L da Silva Siqueira, F Majolo, APB da Silva… - Molecular Biology …, 2021 - Springer
Neurogenesis was believed to end after the period of embryonic development. However, the
possibility of obtaining an expressive number of cells with functional neuronal characteristics …