The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …

This review highlights recent and ongoing discoveries that are transforming the previously
held view of dyad structure and function. New data show that dyads vary greatly in both …

The FK506-binding proteins (FKBP12 and FKBP12. 6; also known as FKBP1A and FKBP1B,
respectively) are accessory subunits of the ryanodine receptor (RyR) Ca2+ release channel …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a lethal genetic
arrhythmia that manifests syncope or sudden death in children and young adults under …

Idiopathic ventricular fibrillation (IVF) causes sudden death in young adult patients without
structural or ischemic heart disease. Most IVF cases are sporadic and some patients present …

A reflection of the explosion of research and development in this field, this book explores
applications of omics in bioinformatics, cancer research and therapy, diabetes research …

Junctin, a non-catalytic splice variant encoded by the aspartate-β-hydroxylase (Asph) gene,
is inserted into the membrane of the sarcoplasmic reticulum (SR) Ca2+ store where it …

Of the major cellular antioxidant defenses, glutathione (GSH) is particularly important in
maintaining the cytosolic redox potential. Whereas the healthy myocardium is maintained at …

The contractile function of the heart requires the release of C a2+ from intracellular C a2+
stores in the sarcoplasmic reticulum (SR) of cardiac muscle cells. The efficacy of C a2+ …

The ryanodine receptor (RyR) is an ion channel composed of four identical subunits
mediating calcium efflux from the endo/sarcoplasmic reticulum of excitable and non …