Molecular, subcellular, and arrhythmogenic mechanisms in genetic RyR2 disease
ED Fowler, S Zissimopoulos - Biomolecules, 2022 - mdpi.com
The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …
Microarchitecture of the dyad
DRL Scriven, P Asghari, EDW Moore - Cardiovascular research, 2013 - academic.oup.com
This review highlights recent and ongoing discoveries that are transforming the previously
held view of dyad structure and function. New data show that dyads vary greatly in both …
held view of dyad structure and function. New data show that dyads vary greatly in both …
Disparities in the association of the ryanodine receptor and the FK506-binding proteins in mammalian heart
S Zissimopoulos, S Seifan, C Maxwell… - Journal of cell …, 2012 - journals.biologists.com
The FK506-binding proteins (FKBP12 and FKBP12. 6; also known as FKBP1A and FKBP1B,
respectively) are accessory subunits of the ryanodine receptor (RyR) Ca2+ release channel …
respectively) are accessory subunits of the ryanodine receptor (RyR) Ca2+ release channel …
[HTML][HTML] RyR2R420Q catecholaminergic polymorphic ventricular tachycardia mutation induces bradycardia by disturbing the coupled clock pacemaker mechanism
YY Wang, P Mesirca, E Marqués-Sulé… - JCI insight, 2017 - ncbi.nlm.nih.gov
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a lethal genetic
arrhythmia that manifests syncope or sudden death in children and young adults under …
arrhythmia that manifests syncope or sudden death in children and young adults under …
A SPRY1 domain cardiac ryanodine receptor variant associated with short-coupled torsade de pointes
Z Touat-Hamici, M Blancard, R Ma, L Lin, Y Iddir… - Scientific Reports, 2021 - nature.com
Idiopathic ventricular fibrillation (IVF) causes sudden death in young adult patients without
structural or ischemic heart disease. Most IVF cases are sporadic and some patients present …
structural or ischemic heart disease. Most IVF cases are sporadic and some patients present …
[图书][B] OMICS: biomedical perspectives and applications
D Barh, K Blum, MA Madigan - 2016 - books.google.com
A reflection of the explosion of research and development in this field, this book explores
applications of omics in bioinformatics, cancer research and therapy, diabetes research …
applications of omics in bioinformatics, cancer research and therapy, diabetes research …
A new cytoplasmic interaction between junctin and ryanodine receptor Ca2+ release channels
L Li, S Mirza, SJ Richardson, EM Gallant… - Journal of cell …, 2015 - journals.biologists.com
Junctin, a non-catalytic splice variant encoded by the aspartate-β-hydroxylase (Asph) gene,
is inserted into the membrane of the sarcoplasmic reticulum (SR) Ca2+ store where it …
is inserted into the membrane of the sarcoplasmic reticulum (SR) Ca2+ store where it …
Regulation of sarcoplasmic reticulum Ca2+ release by cytosolic glutathione in rabbit ventricular myocytes
SR Mazurek, E Bovo, AV Zima - Free Radical Biology and Medicine, 2014 - Elsevier
Of the major cellular antioxidant defenses, glutathione (GSH) is particularly important in
maintaining the cytosolic redox potential. Whereas the healthy myocardium is maintained at …
maintaining the cytosolic redox potential. Whereas the healthy myocardium is maintained at …
Proteins within the intracellular calcium store determine cardiac R y R channel activity and cardiac output
AF Dulhunty, E Wium, L Li, AD Hanna… - Clinical and …, 2012 - Wiley Online Library
The contractile function of the heart requires the release of C a2+ from intracellular C a2+
stores in the sarcoplasmic reticulum (SR) of cardiac muscle cells. The efficacy of C a2+ …
stores in the sarcoplasmic reticulum (SR) of cardiac muscle cells. The efficacy of C a2+ …
N-terminus oligomerization regulates the function of cardiac ryanodine receptors
S Zissimopoulos, C Viero, M Seidel… - Journal of Cell …, 2013 - journals.biologists.com
The ryanodine receptor (RyR) is an ion channel composed of four identical subunits
mediating calcium efflux from the endo/sarcoplasmic reticulum of excitable and non …
mediating calcium efflux from the endo/sarcoplasmic reticulum of excitable and non …