During the past few years, crystallography of G protein–coupled receptors (GPCRs) has
experienced exponential growth, resulting in the determination of the structures of 16 distinct …

The anaphylatoxin (AT) C3a, C5a and C5a-desArg are generally considered pro-
inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in response to …

The activation of the complement cascade, a cornerstone of the innate immune response,
produces a number of small (74–77 amino acid) fragments, originally termed …

G protein–coupled receptors (GPCRs) mediate transmembrane signaling. Before ligand
binding, GPCRs exist in a basal state. Crystal structures of several GPCRs bound with …

Complement fragment (C) 5a is a 74 residue pro‐inflammatory polypeptide produced during
activation of the complement cascade of serum proteins in response to foreign surfaces such …

Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

The concept that G protein‐coupled receptors (GPCRs) can form hetero‐dimers or hetero‐
oligomers continues to gain experimental support. However, with the exception of the …

The complement system is a crucial component of the host response to infection and tissue
damage. Activation of the complement cascade generates anaphylatoxins including C5a …

G‐protein‐coupled receptors are generally thought to be organized as dimers; whether they
form higher order oligomers is a topic of much controversy. We combined bioluminescence …

The C5a receptor (C5aR) is a G-protein-coupled receptor (GPCR) that can induce strong
inflammatory response to the anaphylatoxin C5a. Targeting C5aR has emerged as a novel …