Microfluidic devices: a tool for nanoparticle synthesis and performance evaluation

S Gimondi, H Ferreira, RL Reis, NM Neves - ACS nano, 2023 - ACS Publications
The use of nanoparticles (NPs) in nanomedicine holds great promise for the treatment of
diseases for which conventional therapies present serious limitations. Additionally, NPs can …

Liposomes: Advancements and innovation in the manufacturing process

S Shah, V Dhawan, R Holm, MS Nagarsenker… - Advanced drug delivery …, 2020 - Elsevier
Liposomes are well recognised as effective drug delivery systems, with a range of products
approved, including follow on generic products. Current manufacturing processes used to …

[HTML][HTML] Microfluidic vortex focusing for high throughput synthesis of size-tunable liposomes

JY Han, JN La Fiandra, DL DeVoe - Nature communications, 2022 - nature.com
Control over vesicle size during nanoscale liposome synthesis is critical for defining the
pharmaceutical properties of liposomal nanomedicines. Microfluidic technologies capable of …

[HTML][HTML] Microfluidic synthesis of highly potent limit-size lipid nanoparticles for in vivo delivery of siRNA

NM Belliveau, J Huft, PJC Lin, S Chen… - … Therapy-Nucleic Acids, 2012 - cell.com
Lipid nanoparticles (LNP) are the leading systems for in vivo delivery of small interfering
RNA (siRNA) for therapeutic applications. Formulation of LNP siRNA systems requires rapid …

Liposomes for delivery of antioxidants in cosmeceuticals: Challenges and development strategies

V Van Tran, JY Moon, YC Lee - Journal of controlled release, 2019 - Elsevier
Antioxidants (AOs) play a crucial role in the protection and maintenance of health and are
also integral ingredients in beauty products. Unfortunately, most of them are sensitive due to …

Rapid discovery of potent siRNA-containing lipid nanoparticles enabled by controlled microfluidic formulation

D Chen, KT Love, Y Chen, AA Eltoukhy… - Journal of the …, 2012 - ACS Publications
The discovery of potent new materials for in vivo delivery of nucleic acids depends upon
successful formulation of the active molecules into a dosage form suitable for the …

[HTML][HTML] A review on microfluidic-assisted nanoparticle synthesis, and their applications using multiscale simulation methods

A Agha, W Waheed, I Stiharu, V Nerguizian… - Discover Nano, 2023 - Springer
Recent years have witnessed an increased interest in the development of nanoparticles
(NPs) owing to their potential use in a wide variety of biomedical applications, including drug …

Microfluidic and lab-on-a-chip preparation routes for organic nanoparticles and vesicular systems for nanomedicine applications

L Capretto, D Carugo, S Mazzitelli, C Nastruzzi… - Advanced drug delivery …, 2013 - Elsevier
In recent years, advancements in the fields of microfluidic and lab-on-a-chip technologies
have provided unique opportunities for the implementation of nanomaterial production …

Characterization of lipid nanoparticles containing ionizable cationic lipids using design-of-experiments approach

T Terada, JA Kulkarni, A Huynh, S Chen… - Langmuir, 2021 - ACS Publications
Lipid nanoparticles (LNPs) containing short-interfering RNA (LNP-siRNA systems) are a
promising approach for silencing disease-causing genes in hepatocytes following …

Microfluidics based manufacture of liposomes simultaneously entrapping hydrophilic and lipophilic drugs

S Joshi, MT Hussain, CB Roces, G Anderluzzi… - International journal of …, 2016 - Elsevier
Despite the substantial body of research investigating the use of liposomes, niosomes and
other bilayer vesicles for drug delivery, the translation of these systems into licensed …