[HTML][HTML] Pederins, mycalamides, onnamides and theopederins: Distinctive polyketide families with intriguing therapeutic potentialities
MA Tammam, A El-Demerdash - Current Research in Biotechnology, 2023 - Elsevier
In this comprehensive review article, an in-depth exploration over the period from 1949 to
2023 is presented, focusing on the discovery, chemistry, biosynthesis and therapeutic …
2023 is presented, focusing on the discovery, chemistry, biosynthesis and therapeutic …
[HTML][HTML] Fused tricyclic guanidine alkaloids: Insights into their structure, synthesis and bioactivity
A marine natural product possesses a diverse and unique scaffold that contributes to a vast
array of bioactivities. Tricyclic guanidine alkaloids are a type of scaffold found only in marine …
array of bioactivities. Tricyclic guanidine alkaloids are a type of scaffold found only in marine …
[HTML][HTML] Targeting SARS-CoV-2 endoribonuclease: a structure-based virtual screening supported by in vitro analysis
Researchers are focused on discovering compounds that can interfere with the COVID-19
life cycle. One of the important non-structural proteins is endoribonuclease since it is …
life cycle. One of the important non-structural proteins is endoribonuclease since it is …
Investigating the antiviral therapeutic potentialities of marine polycyclic lamellarin pyrrole alkaloids as promising inhibitors for SARS-CoV-2 and Zika main proteases …
The new coronavirus variant (SARS-CoV-2) and Zika virus are two world-wide health
pandemics. Along history, natural products-based drugs have always crucially recognized …
pandemics. Along history, natural products-based drugs have always crucially recognized …
Anti-breast cancer drugs targeting cell-surface glucose-regulated protein 78: a drug repositioning in silico study
Breast cancer (BC) is prevalent worldwide and is a leading cause of death among women.
However, cell-surface glucose-regulated protein 78 (cs-GRP78) is overexpressed in several …
However, cell-surface glucose-regulated protein 78 (cs-GRP78) is overexpressed in several …
[HTML][HTML] Synthesis and In Silico Study of Some New bis-[1,3,4]thiadiazolimines and bis-Thiazolimines as Potential Inhibitors for SARS-CoV-2 Main Protease
A novel series of bis-[1, 3, 4] thiadiazolimines, and bis-thiazolimines, with alkyl linker, were
synthesized through general routes from cyclization of 1, 1′-(hexane-1, 6-diyl) bis (3 …
synthesized through general routes from cyclization of 1, 1′-(hexane-1, 6-diyl) bis (3 …
In silico structural elucidation of Nipah virus L protein and targeting RNA-dependent RNA polymerase domain by nucleoside analogs
JM Abduljalil, AA Elfiky, ESTA Sayed… - Journal of …, 2023 - Taylor & Francis
The large (L) protein of Mononegavirales is a multi-domain protein that performs
transcription and genome replication. One of the important domains in L is the RNA …
transcription and genome replication. One of the important domains in L is the RNA …
[HTML][HTML] New Guanidine Alkaloids Batzelladines O and P from the Marine Sponge Monanchora pulchra Induce Apoptosis and Autophagy in Prostate Cancer Cells
SA Dyshlovoy, LK Shubina, TN Makarieva, AG Guzii… - Marine Drugs, 2022 - mdpi.com
Two new guanidine alkaloids, batzelladines O (1) and P (2), were isolated from the deep-
water marine sponge Monanchora pulchra. The structures of these metabolites were …
water marine sponge Monanchora pulchra. The structures of these metabolites were …
[PDF][PDF] Current Research in Biotechnology
Metabolic syndrome (MS) represents a global health challenge characterized by various
metabolic disorders, including HOMA-IR (insulin resistance), obesity, dyslipidemia, and …
metabolic disorders, including HOMA-IR (insulin resistance), obesity, dyslipidemia, and …
A Molecular Modeling and Molecular Dynamics Simulations Investigation of the Potential Therapeutic Applications of Main Protease Inhibitors for SARS-CoV-2
AGA Mushebenge, SC Ugbaja, NA Mbatha, RM Khan… - 2023 - preprints.org
A major public health emergency has been created by the COVID-19 pandemic, which is
brought on by the SARS-CoV-2 virus. Due to its crucial function in viral replication, the …
brought on by the SARS-CoV-2 virus. Due to its crucial function in viral replication, the …