Although the cure rates of childhood acute lymphoblastic leukemia (ALL) have improved
dramatically in the past 40 years, not all children have benefited equally from this impressive …

Although somatically acquired genomic alterations have long been recognized as the
hallmarks of acute lymphoblastic leukemia (ALL), the last decade has shown that inherited …

The t (9; 22)(q34; q11) or Philadelphia chromosome creates a BCR–ABL1 fusion gene
encoding for a chimeric BCR–ABL1 protein. It is present in 3–4% of pediatric acute …

Abstract The MRE11, RAD50, and NBN genes encode the MRN complex sensing DNA
breaks and directing their repair. While carriers of biallelic germline pathogenic variants …

Acute leukaemias (AL) correspond to 25–35% of all cancer cases in children. The aetiology
is still sheltered, although several factors are implicated in causality of AL subtypes …

The IKZF 1 gene at 7p12. 2 codes for IKAROS (also termed IKZF 1), an essential
transcription factor in haematopoiesis involved primarily in lymphoid differentiation. Its …

The Ikaros transcription factor is crucial for many aspects of hematopoiesis. Loss of function
mutations in IKZF1, the gene encoding Ikaros, have been implicated in adult and pediatric B …

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and a
leading cause of death due to disease in children. The genetic basis of ALL susceptibility …

Acute lymphoblastic leukemia (ALL) is the most common malignancy in children with distinct
characteristics among different subtypes. Although the etiology of ALL has not been fully …

Mutations and single nucleotide polymorphisms of AT-rich interactive domain-containing
protein 5B (ARID5B) are involved in the oncogenesis of acute lymphoblastic leukemia (ALL) …