Respiratory syncytial virus infection and novel interventions

AC Langedijk, LJ Bont - Nature Reviews Microbiology, 2023 - nature.com
The large global burden of respiratory syncytial virus (RSV) respiratory tract infections in
young children and older adults has gained increased recognition in recent years. Recent …

Respiratory syncytial virus vaccines: a review of the candidates and the approved vaccines

X Topalidou, AM Kalergis, G Papazisis - Pathogens, 2023 - mdpi.com
Respiratory syncytial virus (RSV) is responsible for a significant proportion of global
morbidity and mortality affecting young children and older adults. In the aftermath of formalin …

[HTML][HTML] Efficacy and safety of an mRNA-based RSV PreF vaccine in older adults

E Wilson, J Goswami, AH Baqui… - … England Journal of …, 2023 - Mass Medical Soc
Background Respiratory syncytial virus (RSV) can cause substantial morbidity and mortality
among older adults. An mRNA-based RSV vaccine, mRNA-1345, encoding the stabilized …

[HTML][HTML] Use of respiratory syncytial virus vaccines in older adults: recommendations of the Advisory Committee on Immunization Practices—United States, 2023

M Melgar - MMWR. Morbidity and mortality weekly report, 2023 - cdc.gov
Respiratory syncytial virus (RSV) is a cause of severe respiratory illness in older adults. In
May 2023, the Food and Drug Administration approved the first vaccines for prevention of …

RSV prefusion f protein–based maternal vaccine—preterm birth and other outcomes

I Dieussaert, J Hyung Kim, S Luik, C Seidl… - … England Journal of …, 2024 - Mass Medical Soc
Background Vaccination against respiratory syncytial virus (RSV) during pregnancy may
protect infants from RSV disease. Efficacy and safety data on a candidate RSV prefusion F …

[HTML][HTML] Disease severity of respiratory syncytial virus compared with COVID-19 and influenza among hospitalized adults aged≥ 60 years—IVY network, 20 US States …

D Surie - MMWR. Morbidity and mortality weekly report, 2023 - cdc.gov
Abstract On June 21, 2023, CDC's Advisory Committee on Immunization Practices
recommended respiratory syncytial virus (RSV) vaccination for adults aged≥ 60 years …

The road to approved vaccines for respiratory syncytial virus

TJ Ruckwardt - NPJ vaccines, 2023 - nature.com
After decades of work, several interventions to prevent severe respiratory syncytial virus
(RSV) disease in high-risk infant and older adult populations have finally been approved …

The role of vaccination in COPD: influenza, SARS-CoV-2, pneumococcus, pertussis, RSV and varicella zoster virus

S Simon, O Joean, T Welte… - European Respiratory …, 2023 - Eur Respiratory Soc
Exacerbations of COPD are associated with worsening of the airflow obstruction,
hospitalisation, reduced quality of life, disease progression and death. At least 70% of …

Respiratory syncytial virus prefusion F protein vaccine is efficacious in older adults with underlying medical conditions

RG Feldman, R Antonelli-Incalzi… - Clinical Infectious …, 2024 - academic.oup.com
Background Older adults with chronic cardiorespiratory or endocrine/metabolic conditions
are at increased risk of respiratory syncytial virus (RSV)-related acute respiratory illness …

Intranasal parainfluenza virus type 5 (PIV5)–vectored RSV vaccine is safe and immunogenic in healthy adults in a phase 1 clinical study

P Spearman, H Jin, K Knopp, P Xiao, MC Gingerich… - Science …, 2023 - science.org
Respiratory syncytial virus (RSV) can lead to serious disease in infants, and no approved
RSV vaccine is available for infants. This first in-human clinical trial evaluated a single dose …