State-of-the-art materials for ultrasound-triggered drug delivery

SR Sirsi, MA Borden - Advanced drug delivery reviews, 2014 - Elsevier
Ultrasound is a unique and exciting theranostic modality that can be used to track drug
carriers, trigger drug release and improve drug deposition with high spatial precision. In this …

Phase-change contrast agents for imaging and therapy

PS Sheeran, PA Dayton - Current pharmaceutical design, 2012 - ingentaconnect.com
Phase-change contrast agents (PCCAs) for ultrasound-based applications have resulted in
novel ways of approaching diagnostic and therapeutic techniques beyond what is possible …

Design of ultrasonically-activatable nanoparticles using low boiling point perfluorocarbons

PS Sheeran, SH Luois, LB Mullin, TO Matsunaga… - Biomaterials, 2012 - Elsevier
Recently, an interest has developed in designing biomaterials for medical ultrasonics that
can provide the acoustic activity of microbubbles, but with improved stability in vivo and a …

Acoustic droplet vaporization is initiated by superharmonic focusing

O Shpak, M Verweij, HJ Vos… - Proceedings of the …, 2014 - National Acad Sciences
Acoustically sensitive emulsion droplets composed of a liquid perfluorocarbon have the
potential to be a highly efficient system for local drug delivery, embolotherapy, or for tumor …

Ultrasound-guided therapeutic focused ultrasound: current status and future directions

ES Ebbini, G Ter Haar - International journal of hyperthermia, 2015 - Taylor & Francis
This paper reviews ultrasound imaging methods for the guidance of therapeutic focused
ultrasound (USgFUS), with emphasis on real-time preclinical methods. Guidance is …

Characterization of submicron phase-change perfluorocarbon droplets for extravascular ultrasound imaging of cancer

R Williams, C Wright, E Cherin, N Reznik, M Lee… - Ultrasound in medicine …, 2013 - Elsevier
Because many tumors possess blood vessels permeable to particles with diameters of 200
nm, it is possible that submicron perfluorocarbon droplets could constitute a novel …

Targeted drug delivery with focused ultrasound-induced blood-brain barrier opening using acoustically-activated nanodroplets

CC Chen, PS Sheeran, SY Wu, OO Olumolade… - Journal of Controlled …, 2013 - Elsevier
Focused ultrasound (FUS) in the presence of systemically administered microbubbles has
been shown to locally, transiently and reversibly increase the permeability of the blood …

Contrast-enhanced ultrasound imaging and in vivo circulatory kinetics with low-boiling-point nanoscale phase-change perfluorocarbon agents

PS Sheeran, JD Rojas, C Puett, J Hjelmquist… - Ultrasound in medicine …, 2015 - Elsevier
Many studies have explored phase-change contrast agents (PCCAs) that can be vaporized
by an ultrasonic pulse to form microbubbles for ultrasound imaging and therapy. However …

Materials chemistry of nanoultrasonic biomedicine

H Tang, Y Zheng, Y Chen - Advanced Materials, 2017 - Wiley Online Library
As a special cross‐disciplinary research frontier, nanoultrasonic biomedicine refers to the
design and synthesis of nanomaterials to solve some critical issues of ultrasound (US) …

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

ST Fateh, L Moradi, E Kohan… - Beilstein Journal of …, 2021 - beilstein-journals.org
The field of theranostics has been rapidly growing in recent years and nanotechnology has
played a major role in this growth. Nanomaterials can be constructed to respond to a variety …