Regulatory T cells (Tregs) are abundant in tumor tissues, raising a question of whether
immunosuppressive tumor-infiltrating Tregs (TI-Tregs) can be selectively depleted or …

Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …

Glioblastomas are aggressive primary brain tumors with an inherent resistance to T cell-
centric immunotherapy due to their low mutational burden and immunosuppressive tumor …

Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma trials. Here, we
found that ICBs induce cerebral edema in some patients and mice with glioblastoma …

Regulatory T (Treg) cells maintain immune homeostasis by inhibiting abnormal/overactive
immune responses to both autogenic and nonautogenic antigens. Treg cells play an …

As one of the four major means of cancer treatment including surgery, radiotherapy (RT),
chemotherapy, immunotherapy, RT can be applied to various cancers as both a radical …

Immune checkpoint blockade (ICB) has rapidly transformed the treatment paradigm for
various cancer types. Multiple single or combinations of ICB treatments have been approved …

Glioblastoma multiforme (GBM) is the most malignant intracranial tumor in adults,
characterized by extensive infiltrative growth, high vascularization, and resistance to multiple …

Immunotherapies like the adoptive transfer of gene-engineered T cells and immune
checkpoint inhibitors are novel therapeutic modalities for advanced cancers. However, some …

Chimeric antigen receptor (CAR)-T cells have revolutionized the treatment of multiple types
of hematological malignancies, but have shown limited efficacy in patients with glioblastoma …