Down syndrome (DS), trisomy of human chromosome 21 (Hsa21), is challenging to model in
mice. Not only is it a contiguous gene syndrome spanning 35 Mb of the long arm of Hsa21 …

Down syndrome is caused by trisomy of chromosome 21. To date, a multiplicity of mouse
models with Down-syndrome-related features has been developed to understand this …

At the present time, no viable treatment exists for cognitive and olfactory deficits in Down
syndrome (DS). We show in a DS model (Ts65Dn mice) that these progressive …

Animal models of Down syndrome (DS), trisomic for human chromosome 21 (HSA21) genes
or orthologs, provide insights into better understanding and treatment options. The only …

Down syndrome (DS) is caused by trisomy of human chromosome 21 (Hsa21). The
understanding of genotype–phenotype relationships, the identification of driver genes and …

Abstract β-amyloid precursor protein (APP) and amyloid beta peptide (Aβ) are strongly
implicated in Alzheimer's disease (AD) pathogenesis, although recent evidence has linked …

Trisomy 21 results in gene‐dosage imbalance during embryogenesis and throughout life,
ultimately causing multiple anomalies that contribute to the clinical manifestations of Down …

The genotype–phenotype relationship and the physiopathology of Down Syndrome (DS)
have been explored in the last 20 years with more and more relevant mouse models. From …

Skeletal insufficiency affects all individuals with Down syndrome (DS) or trisomy 21 and may
alter bone strength throughout development due to a reduced period of bone formation and …

Trisomy 21 and mutations in the Sonic hedgehog (SHH) signaling pathway cause
overlapping and pleiotropic phenotypes including cerebellar hypoplasia, craniofacial …