Formins are highly conserved proteins that have essential roles in remodelling the actin and
microtubule cytoskeletons to influence eukaryotic cell shape and behaviour. Recent work …

Protein N-myristoylation is a cotranslational lipidic modification specific to the alpha-amino
group of an N-terminal glycine residue of many eukaryotic and viral proteins. The ubiquitous …

The invasion of cancer cells into the surrounding tissue is a prerequisite and initial step in
metastasis, which is the leading cause of death from cancer. Invasive cell migration requires …

Adoptive transfer of T cells expressing transgenic T-cell receptors (TCRs) with antitumor
function is a hopeful new therapy for patients with advanced tumors; however, there is a …

Podosomes are highly dynamic actin‐rich adhesion structures in cells of myeloid lineage
and some transformed cells. Unlike transformed mesenchymal cell types, podosomes are …

Formin-like 1 (FMNL1) is a member of the formin family of actin nucleators, and is one of the
few formins for which in vitro activities have been well characterized. However, the functional …

The formin protein formin-like 1 (FMNL1) is highly restrictedly expressed in hematopoietic
lineage-derived cells and has been previously identified as a tumor-associated antigen …

Approximately 40% of patients with non-small cell lung cancer (NSCLC) develop bone
metastasis. The formin protein formin-like 1 (FMNL1) plays a key role in the pathogenic …

Almost 25 years have passed since a mutation of a formin gene, DIAPH1, was identified as
being responsible for a human inherited disorder: a form of sensorineural hearing loss …

Pregnancy-associated plasma protein-A (PAPPA), also known as pappalysin, is a member
of the insulin-like growth factor (IGF) family. PAPPA acts as a protease, cleaving IGF …