Abstract The Rho GTPases—RHOA, RAC1 and CDC42—are small GTP binding proteins
that regulate basic biological processes such as cell locomotion, cell division and …

Cytokinesis, the final step in cell division, partitions the contents of a single cell into two. In
animal cells, cytokinesis occurs through cortical remodeling orchestrated by the anaphase …

Animal cell cytokinesis results from patterned activation of the small GTPase Rho, which
directs assembly of actomyosin in the equatorial cortex. Cytokinesis is restricted to a portion …

Cytokinesis mediates the physical separation of dividing cells after chromosome
segregation. In animal cell cytokinesis, a contractile ring, mainly composed of actin and …

Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …

Contractile actin cortex is involved in cell morphogenesis, movement, and cytokinesis, but its
organization and assembly are poorly understood. During blebbing, the membrane …

Cytokinesis is the process by which mitotic cells physically split in two following
chromosome segregation. Dividing animal cells first ingress a cytokinetic furrow and then …

Since it has become clear that adhesion receptors are trafficked through the endosomal
pathway and that this can influence their function, much effort has been invested in obtaining …

Motile eukaryotic cells polarize in response to external signals. Numerous mechanisms
have been suggested to account for this symmetry breaking and for the ensuing robust …

Cells are active materials; they can change shape using internal energy to build contractile
networks of actin filaments and myosin motors. Contractility of the actomyosin cortex is tightly …