This review provides the reader a concise overview of the majority of prodrug approaches
with the emphasis on the modern approaches to prodrug design. The chemical approach …

Enzymes are highly specific biological catalysts that accelerate the rate of chemical
reactions within the cell. Our knowledge of how enzymes work remains incomplete …

The palatability of the active ingredient of a drug is a significant obstacle in developing a
patient friendly dosage form. Organoleptic properties, such as taste, are an important factor …

Introduction: Drug discovery is a lengthy interdisciplinary approach. However, a much
cheaper and less consuming predrug approach is a promising and well-established strategy …

In this chapter we attempt to present a novel prodrug approach which is based on enzyme
models that have been advocated to understand the mechanism by which enzymes catalyze …

Based on DFT, MP2, and the density functional from Truhlar group (hybrid GGA: MPW1k)
calculations for an acid‐catalyzed hydrolysis of nine Kirby's N‐alkylmaleamic acids and two …

As the role of taste receptors in food-intake regulation is being unraveled, agonists and
antagonists of bitter taste receptors will have additional important roles in modulating food …

Introduction: Utilizing the prodrug approach as a method to overcome various
pharmaceutical and pharmacokinetic barriers to drug delivery is significantly accelerating …

Abstract prodrugs are bioreversible derivatives of drug molecules that undergo
intermolecular or intramolecular reactions by enzymatic or chemical biotransformation in the …

The focus of this chapter has been to describe and analyze prodrug approach using
quantum molecular orbital methods toward enhancing bioavailability of the antimalarial …