Acute chest syndrome (ACS) is a frequent cause of acute lung disease in children with sickle
cell disease (SCD). Patients may present with ACS or may develop this complication during …

In the 100 years since sickle cell anemia (SCA) was first described in the medical literature,
studies of its molecular and pathophysiological basis have been at the vanguard of scientific …

The prevention and treatment of acute chest syndrome (ACS) is a major clinical concern in
sickle cell disease (SCD). However, the mechanism underlying the pathogenesis of ACS …

Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

Sickle cell disease, a common single gene disorder, has a complex pathophysiology that at
its root is initiated by the polymerization of deoxy sickle hemoglobin. Sickle vasoocclusion …

Background Genetic variation at loci influencing adult levels of HbF have been shown to
modify the clinical course of sickle cell disease (SCD). Data on this important aspect of SCD …

Introduction Sickle cell disease, one of the world's most prevalent Mendelian disorders, is a
chronic hemolytic anemia punctuated by acute vasoocclusive events. Both hemolysis and …

Acute chest syndrome is a frequent cause of acute lung disease in children with sickle-cell
disease. Asthma is common in children with sickle-cell disease and is associated with …

We aimed to investigate the clinical and genetic predictors of painful vaso‐occlusive crises
(VOC) in sickle cell disease (SCD) in Cameroon. Socio‐demographics, clinical …

SCD is now recognized as a complex disease characterized by acute and chronic
inflammation. The incidence of nearly every clinical manifestation of SCD correlates with …