Tau-targeting therapies for Alzheimer disease: current status and future directions
Alzheimer disease (AD) is the most common cause of dementia in older individuals. AD is
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …
Autism spectrum disorder: neurodevelopmental risk factors, biological mechanism, and precision therapy
L Wang, B Wang, C Wu, J Wang, M Sun - International journal of …, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a heterogeneous, behaviorally defined
neurodevelopmental disorder. Over the past two decades, the prevalence of autism …
neurodevelopmental disorder. Over the past two decades, the prevalence of autism …
Cis P-tau is a central circulating and placental etiologic driver and therapeutic target of preeclampsia
Preeclampsia (PE) is the leading cause of maternal and fetal mortality globally and may
trigger dementia later in life in mothers and their offspring. However, the etiological drivers …
trigger dementia later in life in mothers and their offspring. However, the etiological drivers …
Disrupting pathologic phase transitions in neurodegeneration
BT Hurtle, L Xie, CJ Donnelly - The Journal of clinical …, 2023 - Am Soc Clin Investig
Solid-like protein deposits found in aged and diseased human brains have revealed a
relationship between insoluble protein accumulations and the resulting deficits in neurologic …
relationship between insoluble protein accumulations and the resulting deficits in neurologic …
P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy
D Zhang, W Zhang, C Ming, X Gao, H Yuan, X Lin… - Neuron, 2024 - cell.com
Neuronal loss is the central issue in Alzheimer's disease (AD), yet no treatment developed
so far can halt AD-associated neurodegeneration. Here, we developed a monoclonal …
so far can halt AD-associated neurodegeneration. Here, we developed a monoclonal …
The interaction and pathogenesis between cognitive impairment and common cardiovascular diseases in the elderly
W Zuo, J Wu - Therapeutic Advances in Chronic Disease, 2022 - journals.sagepub.com
Both cognitive impairment and cardiovascular diseases have a high incidence in the elderly
population, increasing the burden of care and reducing the quality of life. Studies have …
population, increasing the burden of care and reducing the quality of life. Studies have …
miR-143-3p inhibits aberrant tau phosphorylation and amyloidogenic processing of APP by directly targeting DAPK1 in Alzheimer's disease
L Wang, X Shui, Y Mei, Y Xia, G Lan, L Hu… - International Journal of …, 2022 - mdpi.com
The neuropathology of Alzheimer's disease (AD) is characterized by intracellular
aggregation of hyperphosphorylated tau and extracellular accumulation of beta-amyloid …
aggregation of hyperphosphorylated tau and extracellular accumulation of beta-amyloid …
Function and regulation of cis P‐tau in the pathogenesis and treatment of conventional and nonconventional tauopathies
Conventional tauopathies are a group of disease characterized by tau inclusions in the
brains, including Alzheimer's disease (AD), Pick's disease (PiD), progressive supranuclear …
brains, including Alzheimer's disease (AD), Pick's disease (PiD), progressive supranuclear …
Mapping the current trends and hotspots of vascular cognitive impairment from 2000–2021: a bibliometric analysis
X Han, J Zhang, S Chen, W Yu… - CNS Neuroscience & …, 2023 - Wiley Online Library
Aims To visualize the trends and hotspots in the scientific research related to vascular
cognitive impairment (VCI) quantitatively and qualitatively. Methods Cross‐sectional …
cognitive impairment (VCI) quantitatively and qualitatively. Methods Cross‐sectional …
Death-associated protein kinase 1 as a therapeutic target for Alzheimer's disease
T Zhang, BM Kim, TH Lee - Translational neurodegeneration, 2024 - Springer
Alzheimer's disease (AD) is the most prevalent form of dementia in the elderly and
represents a major clinical challenge in the ageing society. Neuropathological hallmarks of …
represents a major clinical challenge in the ageing society. Neuropathological hallmarks of …