Sirtuin is an essential factor that delays cellular senescence and extends the organismal
lifespan through the regulation of diverse cellular processes. Suppression of cellular …

Sirtuin 1 (SIRT1) regulates inflammation, aging (life span and health span), calorie
restriction/energetics, mitochondrial biogenesis, stress resistance, cellular senescence …

▪ Abstract The yeast SIR protein complex has been implicated in transcription silencing and
suppression of recombination. The Sir complex represses transcription at telomeres, mating …

Aging is a degenerative process associated with cumulative damage, which leads to cellular
dysfunction, tissue failure, and disorders of body function. Silent information regulator-1, also …

Sir2 (silent information regulator 2) is an NAD+-dependent histone deacetylase that
contributes to longevity in yeast. SIRT1, a mammalian Sir2 ortholog, deacetylates histones …

We characterized human SirT1, one of the human homologs of the budding yeast Sir2p, an
NAD+-dependent histone deacetylase involved in establishing repressive chromatin and …

Summary Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases
dependent on nicotine adenine dinucleotide (NAD) and are found in organisms ranging …

The nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase Sir2
regulates life-span in various species. Mammalian homologs of Sir2 are called sirtuins …

The yeast Sir2p protein has an essential role in maintaining telomeric and mating type
genes in their transcriptionally inactive state. Mammalian cells have a very large proportion …

Transposable elements (TEs) are mobile genetic elements, highly enriched in
heterochromatin, that constitute a large percentage of the DNA content of eukaryotic …