Oxidative stress in human pathology and aging: molecular mechanisms and perspectives

YA Hajam, R Rani, SY Ganie, TA Sheikh, D Javaid… - Cells, 2022 - mdpi.com
Reactive oxygen and nitrogen species (RONS) are generated through various endogenous
and exogenous processes; however, they are neutralized by enzymatic and non-enzymatic …

Effects of diet, lifestyle, chrononutrition and alternative dietary interventions on postprandial glycemia and insulin resistance

E Papakonstantinou, C Oikonomou, G Nychas… - Nutrients, 2022 - mdpi.com
As years progress, we are found more often in a postprandial than a postabsorptive state.
Chrononutrition is an integral part of metabolism, pancreatic function, and hormone …

Molecular mechanisms of ROS production and oxidative stress in diabetes

P Newsholme, VF Cruzat, KN Keane… - Biochemical …, 2016 - portlandpress.com
Oxidative stress and chronic inflammation are known to be associated with the development
of metabolic diseases, including diabetes. Oxidative stress, an imbalance between oxidative …

Nutrients and oxidative stress: friend or foe?

BL Tan, ME Norhaizan… - Oxidative medicine and …, 2018 - Wiley Online Library
There are different types of nutritionally mediated oxidative stress sources that trigger
inflammation. Much information indicates that high intakes of macronutrients can promote …

Obesity and COVID-19: molecular mechanisms linking both pandemics

A Ritter, NN Kreis, F Louwen, J Yuan - International journal of molecular …, 2020 - mdpi.com
The coronavirus disease 2019 COVID-19 pandemic is rapidly spreading worldwide and is
becoming a major public health crisis. Increasing evidence demonstrates a strong …

Regulation of postabsorptive and postprandial glucose metabolism by insulin-dependent and insulin-independent mechanisms: an integrative approach

GD Dimitriadis, E Maratou, A Kountouri, M Board… - Nutrients, 2021 - mdpi.com
Glucose levels in blood must be constantly maintained within a tight physiological range to
sustain anabolism. Insulin regulates glucose homeostasis via its effects on glucose …

Implicating the effect of ketogenic diet as a preventive measure to obesity and diabetes mellitus

S Kumar, T Behl, M Sachdeva, A Sehgal, S Kumari… - Life sciences, 2021 - Elsevier
Obesity and diabetes are the two major metabolic complications linked with bad eating
habits and the sedentary (lazy) lifestyle. In the worst-case situation, metabolic problems are …

Oxidative toxicity in diabetes and Alzheimer's disease: mechanisms behind ROS/RNS generation

W Ahmad, B Ijaz, K Shabbiri, F Ahmed… - Journal of biomedical …, 2017 - Springer
Reactive oxidative species (ROS) toxicity remains an undisputed cause and link between
Alzheimer's disease (AD) and Type-2 Diabetes Mellitus (T2DM). Patients with both AD and …

Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer's disease

G Verdile, KN Keane, VF Cruzat, S Medic… - Mediators of …, 2015 - Wiley Online Library
Type 2 diabetes (T2DM), Alzheimer's disease (AD), and insulin resistance are age‐related
conditions and increased prevalence is of public concern. Recent research has provided …

Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β‐Cell Dysfunction

KN Keane, VF Cruzat, R Carlessi… - Oxidative medicine …, 2015 - Wiley Online Library
The prevalence of diabetes mellitus (DM) is increasing worldwide, a consequence of the
alarming rise in obesity and metabolic syndrome (MetS). Oxidative stress and inflammation …