The main characteristic of alcohol use disorder is the consumption of large quantities of
alcohol despite the negative consequences. The transition from the moderate use of alcohol …

Addiction is a widespread public health issue with social and economic ramifications.
Substance abuse disorders are often accompanied by disruptions in circadian rhythms …

Bipolar disorder (BD) is the sixth leading cause of disability in the world according to the
World Health Organization and affects nearly six million (∼ 2.5% of the population) adults in …

Circadian rhythms are prominent in many physiological and behavioral functions. Circadian
disruptions either by environmental or molecular perturbation can have profound health …

Background Substance use disorders are associated with disruptions in circadian rhythms.
Both human and animal work have shown the integral role for circadian clocks in the …

Experimental and epidemiological evidence reveal the profound influence that industrialized
modern society has imposed on human social habits and physiology during the past 50 …

Circadian rhythms convergently evolved to allow for optimal synchronization of individuals'
physiological and behavioral processes with the Earth's 24-h periodic cycling of …

The circadian clock system drives daily rhythms in physiology, metabolism, and behavior in
mammals. Molecular mechanisms of this system consist of multiple clock genes, with …

Altered behavioral rhythms are a fundamental diagnostic feature of mood disorders. Patients
report worse subjective sleep and objective measures confirm this, implicating a role for …

Background Circadian gene disruptions are associated with the development of psychiatric
disorders, including addiction. However, the mechanisms by which circadian genes regulate …