Protozoan parasites have developed elaborate motility systems that facilitate infection and
dissemination. For example, amoebae use actin-rich membrane extensions called …

Apicomplexan parasites of the genus Eimeria are organisms which invade the intestinal
tract, causing coccidiosis, an enteric disease of major economic importance worldwide. The …

One of the hallmarks of the parasitic phylum of Apicomplexa is the presence of highly
specialised, apical secretory organelles, called the micronemes and rhoptries that play …

Cryptosporidium is a leading infectious cause of diarrhea around the world associated with
waterborne outbreaks, community spread, or zoonotic transmission. The parasite has …

Apicomplexan parasites cause persistent mortality and morbidity worldwide through
diseases including malaria, toxoplasmosis, and cryptosporidiosis. Ca 2+ signaling pathways …

Human malaria, caused by infection with Plasmodium parasites, remains one of the most
important global public health problems, with the World Health Organization reporting more …

Apicomplexan parasites rely on cyclic nucleotide-dependent kinases for host cell infection,
yet the mechanisms that control their activation remain unknown. Here we show that an …

Micronemes and rhoptries are specialized secretory organelles that deploy their contents at
the apical tip of apicomplexan parasites in a regulated manner. The secretory proteins …

The Apicomplexa phylum includes a large group of obligate intracellular protozoan
parasites responsible for important diseases in humans and animals. Toxoplasma gondii is …

Fundamental processes that govern the lytic cycle of the intracellular parasite Toxoplasma
gondii are regulated by several signalling pathways. However, how these pathways are …