Transplantation in the rat model of Parkinson's disease: ectopic versus homotopic graft placement

C Winkler, D Kirik, A Björklund, SB Dunnett - Progress in brain research, 2000 - Elsevier
Publisher Summary This chapter discusses the attempts to improve the functional efficacy of
fetal nigral transplants, focusing on three major questions. First, to what extent is it possible …

MPTP‐induced deficits in striatal synaptic plasticity are prevented by glial cell line‐derived neurotrophic factor expressed via an adeno‐associated viral vector

YH Chen, BK Harvey, AF Hoffman, Y Wang… - The FASEB …, 2008 - Wiley Online Library
This study determined the consequences of dopamine denervation of the striatum on
synaptic plasticity and prevention of these changes with gene therapy using an adeno …

Dopamine depletion causes fragmented clustering of neurons in the sensorimotor striatum: evidence of lasting reorganization of corticostriatal input

J Cho, D Duke, L Manzino… - Journal of …, 2002 - Wiley Online Library
Firing during sensorimotor exam was used to categorize single neurons in the lateral
striatum of awake, unrestrained rats. Five rats received unilateral injection of 6 …

Regulation of neuropeptide mRNA expression in the basal ganglia by intrastriatal and intranigral transplants in the rat Parkinson model

C Winkler, C Bentlage, MA Cenci, G Nikkhah… - Neuroscience, 2003 - Elsevier
Previous studies have shown that intrastriatal transplants of dopamine (DA)-rich fetal ventral
mesencephalic (VM) tissue can correct denervation-induced changes in the cellular …

도파민성신경세포이식후파킨슨병모델흰쥐줄무늬체에서의변화

백선용, 박수정, 정현실, 김영훈, 김혜진… - 대한해부 …, 2001 - scholar.kyobobook.co.kr
흑색질줄무늬체신경로의 손상을 야기하여 파킨슨병모델 흰쥐를 제작하고 실험적인
치료목적으로 줄무늬체에 태서 중 간뇌 세포와 tyrosine hydroxylase (TH) 유전자를 …