[HTML][HTML] Production and isolation of pharmaceutical drug nanoparticles
Nanosizing of pharmaceutical drug particles is one of the most important drug delivery
platforms approaches for the commercial development of poorly water-soluble drug …
platforms approaches for the commercial development of poorly water-soluble drug …
[HTML][HTML] Solid-state and particle size control of pharmaceutical cocrystals using atomization-based techniques
Poor bioavailability and aqueous solubility represent a major constraint during the
development of new API molecules and can influence the impact of new medicines or halt …
development of new API molecules and can influence the impact of new medicines or halt …
SpeedMixing: Rapid tribochemical synthesis and discovery of pharmaceutical cocrystals without milling or grinding media
We present SpeedMixing, a rapid blending technology, as an approach for fast
mechanosynthesis and discovery of model pharmaceutical cocrystals through rapid …
mechanosynthesis and discovery of model pharmaceutical cocrystals through rapid …
[HTML][HTML] Polymorph selection of pharmaceutical cocrystals via bench-top and continuous production techniques
Polymorphism can be a valuable tool as well as an impediment in the development and
approval of pharmaceuticals, providing an opportunity to tune active pharmaceutical …
approval of pharmaceuticals, providing an opportunity to tune active pharmaceutical …
From batch to continuous—New opportunities for supercritical CO2 technology in pharmaceutical manufacturing
Poor solubility and bioavailability of new chemical entities is a major challenge that keeps
plaguing the pharmaceutical industry and jeopardizes their away to the market …
plaguing the pharmaceutical industry and jeopardizes their away to the market …
[HTML][HTML] Amorphization versus cocrystallization of celecoxib-tramadol hydrocholoride using CO2-assisted nano-spray drying
The manipulation of both solid-state form and particle size is a versatile means by which
physicochemical properties of pharmaceutical drugs may be improved/fine-tuned. The work …
physicochemical properties of pharmaceutical drugs may be improved/fine-tuned. The work …
Generation and physicochemical characterization of posaconazole cocrystals using Gas Antisolvent (GAS) and Supercritical Solvent (CSS) methods
Posaconazole (PSZ) is a BCS (biopharmaceutical classification system) Class II anti-fungal
drug used to treat infections in immunocompromised patients. The work presented herein …
drug used to treat infections in immunocompromised patients. The work presented herein …
Amorphous solid dispersion of ibuprofen: A comparative study on the effect of solution based techniques
Amorphous solid dispersion (ASD) is one of the most promising strategies for improving the
solubility of active pharmaceutical ingredients (APIs) with low aqueous solubility. Solvent …
solubility of active pharmaceutical ingredients (APIs) with low aqueous solubility. Solvent …
Crystallization and Polymorphism under Nanoconfinement
Crystallization outcomes, polymorph stability rankings, and phase transformation pathways
can be significantly altered when crystallization is restricted to dimensions below 1 μm. In …
can be significantly altered when crystallization is restricted to dimensions below 1 μm. In …
Unraveling a Unique Metastable Phase of a Proxyphylline Cocrystal Exclusively Produced by Compressed Carbon Dioxide
F Ercicek, M Marchivie, L Nimod, H Cercel… - Crystal Growth & …, 2024 - ACS Publications
In this work, racemic proxyphylline ((±)-PXL, a chiral drug) was cocrystallized for the first time
with 4-hydroxybenzoic acid (4-HBA) from three solvents (acetone, ethyl acetate, and …
with 4-hydroxybenzoic acid (4-HBA) from three solvents (acetone, ethyl acetate, and …