Adenosine triphosphate mediates phase separation of disordered basic proteins by bridging intermolecular interaction networks

D Kota, R Prasad, HX Zhou - Journal of the American Chemical …, 2024 - ACS Publications
Adenosine triphosphate (ATP) is an abundant molecule with crucial cellular roles as the
energy currency and a building block of nucleic acids and for protein phosphorylation. Here …

[HTML][HTML] Amino acid-dependent phase equilibrium and material properties of tetrapeptide condensates

Y Zhang, R Prasad, S Su, D Lee, HX Zhou - Cell Reports Physical Science, 2024 - cell.com
The rules of how amino acids dictate the physical properties of biomolecular condensates
are still incomplete. Here, we study condensates formed by tetrapeptides of the form …

[HTML][HTML] ATP mediates phase separation of disordered basic proteins by bridging intermolecular interaction networks

D Kota, R Prasad, HX Zhou - bioRxiv, 2023 - ncbi.nlm.nih.gov
ATP is an abundant molecule with crucial cellular roles as the energy currency and a
building block of nucleic acids and for protein phosphorylation. Here we show that ATP …

A calibration-free model of micropipette aspiration for measuring properties of protein condensates

JV Roggeveen, H Wang, Z Shi, HA Stone - Biophysical Journal, 2024 - cell.com
There is growing evidence that biological condensates, which are also referred to as
membraneless organelles, and liquid-liquid phase separation play critical roles regulating …

[HTML][HTML] Amino Acid-Dependent Material Properties of Tetrapeptide Condensates

Y Zhang, R Prasad, S Su, D Lee, HX Zhou - bioRxiv, 2024 - ncbi.nlm.nih.gov
Condensates formed by intrinsically disordered proteins mediate a myriad of cellular
processes and are linked to pathological conditions including neurodegeneration. Rules of …

Characterizing properties of biomolecular condensates below the diffraction limit in vivo

G Pandey, A Budhathoki, JH Spille - Phase-Separated Biomolecular …, 2022 - Springer
Fluorescence microscopy assays enable the investigation of endogenous biomolecular
condensates directly in their cellular context. With appropriate experimental designs, these …

Biomolecular Condensates Can Enhance Pathological RNA Clustering

TS Mahendran, GM Wadsworth, A Singh, PR Banerjee - bioRxiv, 2024 - biorxiv.org
Intracellular aggregation of repeat expanded RNA has been implicated in many
neurological disorders. Here, we study the role of biomolecular condensates on irreversible …

Biomolecular condensates can enhance pathological RNA clustering

P Banerjee, TS Mahendran, G Wadsworth… - Research …, 2024 - pmc.ncbi.nlm.nih.gov
Intracellular aggregation of repeat expanded RNA has been implicated in many
neurological disorders. Here, we study the role of biomolecular condensates on irreversible …

Asymmetric and rough boundary effects on particle motions and fluid flows

J Roggeveen - 2024 - search.proquest.com
Particles immersed in a fluid will generally be carried along with that fluid as it flows.
However, the resulting dynamics of the particles varies greatly depending on the geometry …