No other tissue in the body depends more on the composition and organization of the
extracellular matrix (ECM) for normal structure and function than the corneal stroma. The …

The extracellular matrix (ECM) constitutes the main acellular microenvironment of cells in
almost all tissues and organs. The ECM not only provides mechanical support, but also …

Basement membranes are layers of extracellular matrix which anchor the epithelium or
endothelium to connective tissues in most organs. Descemet's membrane—which is the …

Losartan is an angiotensin II receptor blocker (ARB) that impedes transforming growth factor
(TGF) beta signaling by inhibiting activation of signal transduction molecule extracellular …

Various wounds caused by burns, trauma, surgery, and genetic irregularities, including
acute and chronic wounds, pose a huge burden on global healthcare. Many therapeutic …

The extracellular matrix (ECM) is a complex network of biomolecules that mechanically and
biochemically directs cell behavior and is crucial for maintaining tissue function and health …

The cornea, as a dynamic and responsive tissue, constantly interacts with mechanical forces
in order to maintain its structural integrity, barrier function, transparency and refractive …

Mesenchymal cells (keratocytes, corneal fibroblasts, and myofibroblasts), as well as
mesenchymal progenitor bone marrow-derived fibrocytes, are the major cellular contributors …

Every organ develops fibrosis that compromises functions in response to infections, injuries,
or diseases. The cornea is a relatively simple, avascular organ that offers an exceptional …

Cornea, a dome-shaped and transparent front part of the eye, affords 2/3rd refraction and
barrier functions. Globally, corneal diseases are the leading cause of vision impairment …