Precision nutrition aims to make dietary recommendations of a more personalized nature
possible, to optimize the prevention or delay of a disease and to improve health. Therefore …

Objective Systemic lupus erythematosus (SLE) is a highly female-biased systemic
autoimmune disease, but the molecular basis for this female bias remains incompletely …

Sex is a modulator of health that has been historically overlooked in biomedical research.
Recognizing this knowledge gap, funding agencies now mandate the inclusion of sex as a …

The silencing of all but one X chromosome in mammalian cells is a remarkable epigenetic
process leading to near dosage equivalence in X-linked gene products between the sexes …

Background Loss of epigenetic control is a hallmark of aging. Among the most prominent
roles of epigenetic mechanisms is the inactivation of one of two copies of the X chromosome …

DNA methylation is known to be the most stable epigenetic modification and has been
extensively studied in relation to cell differentiation, development, X chromosome …

X chromosome inactivation (XCI) balances X-linked gene dosage between sexes.
Unstimulated T cells lack cytological enrichment of X-inactive specific transcript (Xist) RNA …

Abstract USP9X is an X-chromosome gene that escapes X-inactivation. Loss or
compromised function of USP9X leads to neurodevelopmental disorders in males and …

Background X-chromosome inactivation (XCI) is the epigenetic inactivation of one of two X
chromosomes in XX eutherian mammals. The inactive X chromosome is the result of …

Frailty, a prevalent clinical syndrome in aging adults, is characterized by poor health
outcomes, represented via a standardized frailty-phenotype (FP), and Frailty Index (FI) …