This review proposes that physical inactivity could be considered a behavior selected by
evolution for resting, and also selected to be reinforcing in life-threatening situations in …

Longitudinal multimodal biomarker studies reveal that the continuum of Alzheimer's disease
(AD) includes a long latent phase, referred to as preclinical AD, which precedes the onset of …

Background Cognitive impairment, including dementia, is a major health concern with the
increasing aging population. Preventive measures to delay cognitive decline are of utmost …

With the aging of the population, the burden of Alzheimer's disease (AD) is rapidly
expanding. More than 5 million people in the US alone are affected with AD and this number …

Chronic diseases are major killers in the modern era. Physical inactivity is a primary cause
of most chronic diseases. The initial third of the article considers: activity and prevention …

Summary At present, about 33· 9 million people worldwide have Alzheimer's disease (AD),
and prevalence is expected to triple over the next 40 years. The aim of this Review was to …

Data from epidemiological, cross-sectional, and neuroimaging research show a relationship
between higher levels of exercise and reduced risk of cognitive decline but evidence from …

A rapidly growing literature strongly suggests that exercise, specifically aerobic exercise,
may attenuate cognitive impairment and reduce dementia risk. We used PubMed (keywords …

The benefits of regular exercise, physical fitness and sports participation on cardiovascular
and brain health are undeniable. Physical activity reduces the risk for cardiovascular …

Along with advanced age and apolipoprotein E (APOE)-4 genotype, female sex is a major
risk factor for developing late-onset Alzheimer's disease (AD). Considering that AD …