Polo-like kinases (Plks) are potent regulators of M phase that are conserved from yeasts to
humans. Their roles in mitotic entry, spindle pole functions and cytokinesis are broadly …

The use of fungal model systems, such as Saccharomyces cerevisisae and
Schizosaccharomyces pombe, has contributed enormously to our understanding of …

Background SAK/PLK4 is a distinct member of the polo-like kinase family. SAK−/− mice die
during embryogenesis, whereas SAK+/− mice develop liver and lung tumors and SAK+ …

The ubiquitous nature of protein phosphorylation makes it challenging to map kinase-
substrate relationships, which is a necessary step toward defining signaling network …

Polo‐like kinase‐1 (Plk1) phosphorylates a number of mitotic substrates, but the diversity of
Plk1‐dependent processes suggests the existence of additional targets. Plk1 contains a …

In budding yeast, exit from the pachytene stage of meiosis requires the mid-meiosis
transcription factor Ndt80, which promotes expression of∼ 200 genes. Ndt80 is required for …

Polo-like kinase 1 (Plk1) is required for the generation of the tension-sensing 3F3/2
kinetochore epitope and facilitates kinetochore localization of Mad2 and other spindle …

The links between the cell cycle machinery and the cytoskeletal proteins controlling
cytokinesis are poorly understood. The small guanine nucleotide triphosphate (GTP) …

Polo-like kinase 1 (Plk1) has multiple important functions during M-phase progression. In
addition to a catalytic domain, Plk1 possesses a phosphopeptide-binding motif, the polo-box …

The small GTP-binding protein, Rho1/RhoA plays a central role in cytokinetic actomyosin
ring (CAR) assembly and cytokinesis. Concentration of Rho proteins at the division site is a …