Frailty, an age-related condition of increased vulnerability to acute endogenous or
exogenous stressors, is a key barrier to successful treatment of cancer in older people. In …

As the majority of patients with cancer are older than 65 years, most medical, surgical, and
radiation oncologists treat a large number of older adults in their clinical practice. Older …

Background The effectiveness of comprehensive geriatric assessment (CGA) in improving
health outcomes in cancer settings is unclear. We evaluated whether CGA can improve …

PURPOSE To verify whether both doublet chemotherapy with a modified schedule of
fluorouracil, leucovorin, and oxaliplatin (mFOLFOX) and monochemotherapy with …

Immune checkpoint blockers (ICBs) have a pivotal role in the management of non-small cell
lung cancer (NSCLC), both as single agent and in combination strategies, providing a …

As many countries experience population aging, patients with cancer are becoming older
and have more preexisting comorbidities, which include prevalent, age‐related, chronic …

Frailty, defined as an age-related state of increased vulnerability to acute stressors, is a
major challenge in the care of older people with haematological malignancies. Growing …

The majority of men with prostate cancer are diagnosed when they are older than 65 years;
however, clinical trial participants are disproportionately younger and more fit than the real …

Introduction Frailty is a complex multifactorial syndrome characterised by a significant
increase in vulnerability and worsened health outcomes. Despite a range of proposed frailty …

Background The prevalence of colorectal cancer has remained high. Most patients have
already developed into the middle and advanced stage when they are diagnosed with …