Simple Summary The formation of new blood vessels from already existing ones is a
process of high clinical relevance, since it is of great importance for both physiological and …

Cancer cells undergo genetic changes allowing their adaptation to environmental changes,
thereby obtaining an advantage during the long metastatic route, disseminated of several …

Proteolysis in close vicinity of tumor cells is a hallmark of cancer invasion and metastasis.
We show here that mouse mammary tumor virus–polyoma middle T antigen (PyMT) …

Integrins are heterodimeric cell surface receptors that bind to different extracellular ligands
depending on their composition and regulate all processes which enable multicellular life. In …

Tissue kallikreins are members of the S1 family (clan SA) of trypsin-like serine proteases
and are present in at least six mammalian orders. In humans, tissue kallikreins (hK) are …

The majority of cancer-related deaths are associated with metastasis; however, little is
known about the mechanisms of this process. Hepsin is a cell surface serine protease that is …

TMPRSS2 is a type II transmembrane-bound serine protease that has gained interest owing
to its highly localized expression in the prostate and its overexpression in neoplastic …

Carcinoma-associated fibroblasts (CAFs) are a key determinant in malignant progression of
cancer and represent an important target for cancer therapies. In this work, we present a …

The lysosomal cysteine proteases cathepsin B (Ctsb) and cathepsin Z (Ctsz, also called
cathepsin X/P) have been implicated in cancer pathogenesis. Compensation of Ctsb by Ctsz …

Seprase or Fibroblast Activation Protein (FAP) is an integral membrane serine peptidase,
which has been shown to have gelatinase activity. Seprase has a dual function in tumour …