Spermatogenesis is the cellular process by which spermatogonia develop into mature
spermatids within seminiferous tubules, the functional unit of the mammalian testis, under …

Key events ranging from cell polarity to proliferation regulation to neuronal signaling rely on
the assembly of multiprotein adhesion or signaling complexes at particular subcellular sites …

Neural stem cells (NSCs) contribute to plasticity and repair of the adult brain. Niches
harboring NSCs regulate stem cell self-renewal and differentiation. We used comprehensive …

Extrinsic signals controlling generation of neocortical neurons during embryonic life have
been difficult to identify. In this study we demonstrate that the dorsal forebrain meninges …

Loss of cell polarity proteins such as Scribble induces neoplasia in Drosophila by promoting
uncontrolled proliferation. In mammals, the role that polarity proteins play during …

Abstract Models derived from human pluripotent stem cells that accurately recapitulate
neural development in vitro and allow for the generation of specific neuronal subtypes are of …

Sonic Hedgehog (Shh) signals are transduced into nuclear ratios of Gli transcriptional
activator versus repressor. The initial part of this process is accomplished by Shh acting …

The neoplastic tumour suppressors, Scribble, Dlg and Lgl, originally discovered in the
vinegar fly Drosophila melanogaster, are currently being actively studied for their potential …

Cancer is the result of the deregulation of cell proliferation and cell migration. In advanced
tumors, cells invade the surrounding tissue and eventually form metastases. This is …

Gastrulation and neurulation are successive morphogenetic processes that play key roles in
shaping the basic embryonic body plan. Importantly, they operate through common cellular …