Cognitive impairment associated with schizophrenia: from pathophysiology to treatment
DC Javitt - Annual Review of Pharmacology and Toxicology, 2023 - annualreviews.org
Cognitive impairment is a core feature of schizophrenia and a major contributor to poor
functional outcomes. Methods for assessment of cognitive dysfunction in schizophrenia are …
functional outcomes. Methods for assessment of cognitive dysfunction in schizophrenia are …
How do abnormalities in the brain's spontaneous activity translate into symptoms in schizophrenia? From an overview of resting state activity findings to a proposed …
G Northoff, NW Duncan - Progress in neurobiology, 2016 - Elsevier
Schizophrenia is a complex neuropsychiatric disorder with a variety of symptoms that
include sensorimotor, affective, cognitive, and social changes. The exact neuronal …
include sensorimotor, affective, cognitive, and social changes. The exact neuronal …
Neural mechanisms of mismatch negativity dysfunction in schizophrenia
Schizophrenia is associated with cognitive deficits that reflect impaired cortical information
processing. Mismatch negativity (MMN) indexes pre-attentive information processing …
processing. Mismatch negativity (MMN) indexes pre-attentive information processing …
Improvement in mismatch negativity generation during d-serine treatment in schizophrenia: correlation with symptoms
Background Deficits in N-methyl-d-aspartate-type (NMDAR) function contribute to symptoms
and cognitive dysfunction in schizophrenia. The efficacy of NMDAR agonists in the treatment …
and cognitive dysfunction in schizophrenia. The efficacy of NMDAR agonists in the treatment …
Mismatch negativity as a biomarker of theta band oscillatory dysfunction in schizophrenia
Mismatch negativity (MMN) is among the best established biomarkers of cortical dysfunction
in schizophrenia. MMN generators are localized primarily to primary and secondary auditory …
in schizophrenia. MMN generators are localized primarily to primary and secondary auditory …
Neurophysiological mechanisms of cortical plasticity impairments in schizophrenia and modulation by the NMDA receptor agonist D-serine
JT Kantrowitz, ML Epstein, O Beggel, S Rohrig… - Brain, 2016 - academic.oup.com
Schizophrenia is associated with deficits in cortical plasticity that affect sensory brain regions
and lead to impaired cognitive performance. Here we examined underlying neural …
and lead to impaired cognitive performance. Here we examined underlying neural …
Targeting Serotonin 5-HT2A Receptors to Better Treat Schizophrenia: Rationale and Current Approaches
JT Kantrowitz - CNS drugs, 2020 - Springer
Schizophrenia is a major mental illness associated with profound disability. Current
treatments for schizophrenia (antipsychotics) all have a similar mechanism of action and are …
treatments for schizophrenia (antipsychotics) all have a similar mechanism of action and are …
Meta-analysis of mismatch negativity to simple versus complex deviants in schizophrenia
Mismatch negativity (MMN) deficits in schizophrenia (SCZ) have been studied extensively
since the early 1990s, with the vast majority of studies using simple auditory oddball task …
since the early 1990s, with the vast majority of studies using simple auditory oddball task …
Early auditory processing dysfunction in schizophrenia: Mechanisms and implications
C Dondé, JT Kantrowitz, A Medalia… - Neuroscience & …, 2023 - Elsevier
Schizophrenia is a major mental disorder that affects approximately 1% of the population
worldwide. Cognitive deficits are a key feature of the disorder and a primary cause of long …
worldwide. Cognitive deficits are a key feature of the disorder and a primary cause of long …
Reduced oxytocin receptor gene expression and binding sites in different brain regions in schizophrenia: a post-mortem study
S Uhrig, N Hirth, L Broccoli, M von Wilmsdorff… - Schizophrenia …, 2016 - Elsevier
Schizophrenia is a severe neuropsychiatric disorder with impairments in social cognition.
Several brain regions have been implicated in social cognition, including the nucleus …
Several brain regions have been implicated in social cognition, including the nucleus …