Cognitive impairment associated with schizophrenia: from pathophysiology to treatment

DC Javitt - Annual Review of Pharmacology and Toxicology, 2023 - annualreviews.org
Cognitive impairment is a core feature of schizophrenia and a major contributor to poor
functional outcomes. Methods for assessment of cognitive dysfunction in schizophrenia are …

How do abnormalities in the brain's spontaneous activity translate into symptoms in schizophrenia? From an overview of resting state activity findings to a proposed …

G Northoff, NW Duncan - Progress in neurobiology, 2016 - Elsevier
Schizophrenia is a complex neuropsychiatric disorder with a variety of symptoms that
include sensorimotor, affective, cognitive, and social changes. The exact neuronal …

Neural mechanisms of mismatch negativity dysfunction in schizophrenia

M Lee, P Sehatpour, MJ Hoptman, P Lakatos… - Molecular …, 2017 - nature.com
Schizophrenia is associated with cognitive deficits that reflect impaired cortical information
processing. Mismatch negativity (MMN) indexes pre-attentive information processing …

Improvement in mismatch negativity generation during d-serine treatment in schizophrenia: correlation with symptoms

JT Kantrowitz, ML Epstein, M Lee, N Lehrfeld… - Schizophrenia …, 2018 - Elsevier
Background Deficits in N-methyl-d-aspartate-type (NMDAR) function contribute to symptoms
and cognitive dysfunction in schizophrenia. The efficacy of NMDAR agonists in the treatment …

Mismatch negativity as a biomarker of theta band oscillatory dysfunction in schizophrenia

DC Javitt, M Lee, JT Kantrowitz, A Martinez - Schizophrenia research, 2018 - Elsevier
Mismatch negativity (MMN) is among the best established biomarkers of cortical dysfunction
in schizophrenia. MMN generators are localized primarily to primary and secondary auditory …

Neurophysiological mechanisms of cortical plasticity impairments in schizophrenia and modulation by the NMDA receptor agonist D-serine

JT Kantrowitz, ML Epstein, O Beggel, S Rohrig… - Brain, 2016 - academic.oup.com
Schizophrenia is associated with deficits in cortical plasticity that affect sensory brain regions
and lead to impaired cognitive performance. Here we examined underlying neural …

Targeting Serotonin 5-HT2A Receptors to Better Treat Schizophrenia: Rationale and Current Approaches

JT Kantrowitz - CNS drugs, 2020 - Springer
Schizophrenia is a major mental illness associated with profound disability. Current
treatments for schizophrenia (antipsychotics) all have a similar mechanism of action and are …

Meta-analysis of mismatch negativity to simple versus complex deviants in schizophrenia

M Avissar, S Xie, B Vail, J Lopez-Calderon… - Schizophrenia …, 2018 - Elsevier
Mismatch negativity (MMN) deficits in schizophrenia (SCZ) have been studied extensively
since the early 1990s, with the vast majority of studies using simple auditory oddball task …

Early auditory processing dysfunction in schizophrenia: Mechanisms and implications

C Dondé, JT Kantrowitz, A Medalia… - Neuroscience & …, 2023 - Elsevier
Schizophrenia is a major mental disorder that affects approximately 1% of the population
worldwide. Cognitive deficits are a key feature of the disorder and a primary cause of long …

Reduced oxytocin receptor gene expression and binding sites in different brain regions in schizophrenia: a post-mortem study

S Uhrig, N Hirth, L Broccoli, M von Wilmsdorff… - Schizophrenia …, 2016 - Elsevier
Schizophrenia is a severe neuropsychiatric disorder with impairments in social cognition.
Several brain regions have been implicated in social cognition, including the nucleus …