Retinal circuits transform the pixel representation of photoreceptors into the feature
representations of ganglion cells, whose axons transmit these representations to the brain …

Abstract Structure and function are highly correlated in the vertebrate retina, a sensory tissue
that is organized into cell layers with microcircuits working in parallel and together to encode …

Retinal bipolar cells are the first'projection neurons' of the vertebrate visual system—all of
the information needed for vision is relayed by this intraretinal connection. Each of the at …

Understanding a sensory system implies the ability to predict responses to a variety of inputs
from a common model. In the retina, this includes predicting how the integration of signals …

The activity-dependent rules that govern the wiring of GABAergic interneurons are not well
understood. Chandelier cells (ChCs) are a type of GABAergic interneuron that control …

Although the importance of network connectivity is increasingly recognized, identifying
synapses remains challenging relative to the routine characterization of neuronal …

Electrical and chemical synapses coexist in circuits throughout the CNS. Yet, it is not well
understood how electrical and chemical synaptic transmission interact to determine the …

Vision begins in the retina, whose intricate neural circuits extract salient features of the
environment from the light entering our eyes. Neurodegenerative diseases of the retina (eg …

Highlights•Synaptic activity drives the formation of specific synapses in the retina.•
Neurotransmitter induces the formation of spines in developing cortical neurons.•Axons are …

Neuronal subtype-specific transcription factors (TFs) instruct key features of neuronal
function and connectivity. Activity-dependent mechanisms also contribute to wiring and …