The metabolome, the collection of small-molecule chemical entities involved in metabolism,
has traditionally been studied with the aim of identifying biomarkers in the diagnosis and …

Lactate, the end product of glycolysis, efficiently functions as the carbon source, signaling
molecules and immune regulators. Lactylation, being regulated by lactate, has recently been …

Serial multi-omic analysis of proteome, phosphoproteome, and acetylome provides insights
into changes in protein expression, cell signaling, cross-talk and epigenetic pathways …

Posttranslational modification of a protein, either alone or in combination with other
modifications, can control properties of that protein, such as enzymatic activity, localization …

Protein myristoylation is a C14 fatty acid modification found in all living organisms.
Myristoylation tags either the N-terminal alpha groups of cysteine or glycine residues …

Background Lactate is an important metabolite derived from glycolysis under physiological
and pathological conditions. The Warburg effect reveals the vital role of lactate in cancer …

Lactylation has been recently identified as a new type of posttranslational modification
occurring widely on lysine residues of both histone and nonhistone proteins. The …

Kidney research is entering an era of 'big data'and molecular omics data can provide
comprehensive insights into the molecular footprints of cells. In contrast to transcriptomics …

As a novel protein post-translational modification (PTM), lysine succinylation is widely
involved in metabolism regulation by altering the activity of catalytic enzymes. Inactivating …

Advanced mass spectrometry methods have detected thousands of post-translational
phosphorylation and acetylation sites in bacteria, but their functional role and the enzymes …