Ferroptosis as a mechanism of non-ferrous metal toxicity

M Aschner, AV Skalny, AC Martins, AI Sinitskii… - Archives of …, 2022 - Springer
Ferroptosis is a recently discovered form of regulated cell death, implicated in multiple
pathologies. Given that the toxicity elicited by some metals is linked to alterations in iron …

Modeling inflammation in zebrafish for the development of anti-inflammatory drugs

Y Xie, AH Meijer, MJM Schaaf - Frontiers in cell and developmental …, 2021 - frontiersin.org
Dysregulation of the inflammatory response in humans can lead to various inflammatory
diseases, like asthma and rheumatoid arthritis. The innate branch of the immune system …

Elesclomol induces copper‐dependent ferroptosis in colorectal cancer cells via degradation of ATP7A

W Gao, Z Huang, J Duan, EC Nice, J Lin… - Molecular …, 2021 - Wiley Online Library
Cancer cells reprogram their copper metabolism to adapt to adverse microenvironments,
such as oxidative stress. The copper chelator elesclomol has been reported to have …

Structural characterization and anti-inflammatory activity of neutral polysaccharides from American ginseng

L Xie, H Yan, L Han, L Cui, H Hussain, Q Feng… - International Journal of …, 2023 - Elsevier
American ginseng, a precious classic herbal medicine, is used extensively in China for life
prolongation purpose. This study aimed to elucidate the structure and anti-inflammatory …

CDKN2A-mediated molecular subtypes characterize the hallmarks of tumor microenvironment and guide precision medicine in triple-negative breast cancer

T Cheng, Y Wu, Z Liu, Y Yu, S Sun, M Guo… - Frontiers in …, 2022 - frontiersin.org
Currently, breast cancer (BRCA) has become the most common cancer in the world, whose
pathological mechanism is complex. Among its subtypes, triple-negative breast cancer …

Anti-Inflammatory and Antioxidant Properties of β-Sitosterol in Copper Sulfate-Induced Inflammation in Zebrafish (Danio rerio)

P Zhang, N Liu, M Xue, M Zhang, W Liu, C Xu, Y Fan… - Antioxidants, 2023 - mdpi.com
β-Sitosterol, which is used extensively in pharmaceuticals, nutraceuticals, and cosmetics,
has high nutritional value along with immunomodulatory and anti-inflammatory properties. In …

1H-Pyrazole-4-carboxylic acid-based metal–organic frameworks: multifaceted materials

RK Gupta, P Kallem, GG Luo, P Cui, Z Wang… - Coordination Chemistry …, 2023 - Elsevier
Abstract Metal-organic frameworks (MOFs), consisting of metal ions or clusters coordinated
with organic ligands, are a class of crystalline materials that have garnered widespread …

Serum zinc, copper, and other biometals are associated with COVID-19 severity markers

AV Skalny, PS Timashev, M Aschner, J Aaseth… - Metabolites, 2021 - mdpi.com
The objective of the present study was to evaluate of serum metal levels in COVID-19
patients with different disease severity, and to investigate the independent association …

Hepatic transcriptomic and histopathological responses of common carp, Cyprinus carpio, to copper and microplastic exposure

SM Hoseini, K Khosraviani, FH Delavar… - Marine Pollution …, 2022 - Elsevier
The combined effects of copper and polyvinyl chloride (PVC) microparticles were
investigated on the metal accumulation, histopathological biomarkers, and targeted …

A tandem activation of NLRP3 inflammasome induced by copper oxide nanoparticles and dissolved copper ion in J774A. 1 macrophage

X Tao, X Wan, D Wu, E Song, Y Song - Journal of hazardous materials, 2021 - Elsevier
For the first time, we reported that CuONPs exposure induced interleukin (IL)− 1β-mediated
inflammation via NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) inflammasome …