Nearly all genetic variants that influence disease risk have human-specific origins; however,
the systems they influence have ancient roots that often trace back to evolutionary events …

Genetic architecture describes the characteristics of genetic variation that are responsible for
heritable phenotypic variability. It depends on the number of genetic variants affecting a trait …

The co-occurrence of diseases can inform the underlying network biology of shared and
multifunctional genes and pathways. In addition, comorbidities help to elucidate the effects …

Genome-wide association studies have greatly improved our understanding of the genetic
basis of disease risk. The fact that they tend not to identify more than a fraction of the specific …

Genome-wide association studies have identified hundreds of genetic variants associated
with complex human diseases and traits, and have provided valuable insights into their …

OBJECTIVE Human blood glucose levels have likely evolved toward their current point of
stability over hundreds of thousands of years. The robust population stability of this trait is …

Cryptic genetic variation (CGV) is invisible under normal conditions, but it can fuel evolution
when circumstances change. In theory, CGV can represent a massive cache of adaptive …

Although we generally experience our bodies as being biologically stable across time and
situations, an emerging field of research is demonstrating that external social conditions …

The search for the alleles that matter, the quantitative trait nucleotides (QTNs) that underlie
heritable variation within populations and divergence among them, is a popular pursuit. But …

Enormous progress in mapping complex traits in humans has been made in the last 5 yr.
There has been early success for prevalent diseases with complex phenotypes. These …