The cornea consists primarily of three layers: an outer layer containing an epithelium, a
middle stromal layer consisting of a collagen-rich extracellular matrix (ECM) interspersed …

Gelatin has been used for many years in pharmaceutical formulation, cell culture and tissue
engineering on account of its excellent biocompatibility, ease of processing and availability …

The corneal wound healing cascade is complex and involves stromal–epithelial and stromal–
epithelial–immune interactions mediated by cytokines. Interleukin-1 appears to be a master …

The last 5 years have seen a marked increase in research on keratan sulfate (KS) and a
concomitant increase in our understanding of the range of molecules that carry this …

We present a novel indentation method for characterizing the viscoelastic properties of
alginate and agarose hydrogel based constructs, which are often used as a model system of …

Transplantation of amniotic membrane as a temporary or permanent graft promotes
epithelial wound healing and exerts potent anti-inflammatory and anti-scarring effects on the …

In mammals, penetrating injuries typically heal by deposition of fibrotic “repair tissue” that
fills and seals wounds but does not restore normal function. Excessive deposition of fibrotic …

The purpose of this study was to evaluate specific keratocyte phenotypes (keratocyte,
fibroblast, myofibroblast) for cell contractility and ability to contract extracellular matrix …

In pathological corneas, accumulation of fibrotic extracellular matrix is characterized by
proteoglycans with altered glycosaminoglycans that contribute to the reduced transparency …

Decorin and biglycan are class I small leucine-rich proteoglycans (SLRPs) involved in
regulation of collagen fibril and matrix assembly. We hypothesize that tissue-specific matrix …