Cellular functions of cGAS-STING signaling
C Chen, P Xu - Trends in cell biology, 2023 - cell.com
Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) senses misplaced genomic,
mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2′ 3′-cGAMP …
mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2′ 3′-cGAMP …
Bacterial origins of human cell-autonomous innate immune mechanisms
The cell-autonomous innate immune system enables animal cells to resist viral infection.
This system comprises an array of sensors that, after detecting viral molecules, activate the …
This system comprises an array of sensors that, after detecting viral molecules, activate the …
Immune response in COVID-19: what is next?
Abstract The coronavirus disease 2019 (COVID-19) has been a global pandemic for more
than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A …
than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A …
Structures and mechanisms in the cGAS-STING innate immunity pathway
Besides its role as the blueprint of life, DNA can also alert the cell to the presence of
microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that …
microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that …
DNA sensing by the cGAS–STING pathway in health and disease
The detection of pathogens through nucleic acid sensors is a defining principle of innate
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …
Nanotechnology for COVID-19: therapeutics and vaccine research
The current global health threat by the novel coronavirus disease 2019 (COVID-19) requires
an urgent deployment of advanced therapeutic options available. The role of …
an urgent deployment of advanced therapeutic options available. The role of …
NLRP3 inflammasome—a key player in antiviral responses
C Zhao, W Zhao - Frontiers in immunology, 2020 - frontiersin.org
The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is an
oligomeric complex comprised of the NOD-like receptor NLRP3, the adaptor ASC, and …
oligomeric complex comprised of the NOD-like receptor NLRP3, the adaptor ASC, and …
Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease
Type I interferon (IFN) is a key cytokine that curbs viral infection and cell malignancy.
Previously, we demonstrated a potent IFN immunogenicity of nucleic acid–containing (NA …
Previously, we demonstrated a potent IFN immunogenicity of nucleic acid–containing (NA …
[HTML][HTML] Interferon-independent activities of mammalian STING mediate antiviral response and tumor immune evasion
Type I interferon (IFN) response is commonly recognized as the main signaling activity of
STING. Here, we generate the Sting1 S365A/S365A mutant mouse that precisely ablates …
STING. Here, we generate the Sting1 S365A/S365A mutant mouse that precisely ablates …
Activation of innate immune cGAS-STING pathway contributes to Alzheimer's pathogenesis in 5× FAD mice
Abstract cGAS senses microbial and host-derived double-stranded DNA in cytoplasm to
trigger cellular innate immune response in a STING-dependent manner; however, it remains …
trigger cellular innate immune response in a STING-dependent manner; however, it remains …