The matrix in cancer
TR Cox - Nature Reviews Cancer, 2021 - nature.com
The extracellular matrix is a fundamental, core component of all tissues and organs, and is
essential for the existence of multicellular organisms. From the earliest stages of organism …
essential for the existence of multicellular organisms. From the earliest stages of organism …
The power of imaging to understand extracellular vesicle biology in vivo
Extracellular vesicles (EVs) are nano-sized lipid bilayer vesicles released by virtually every
cell type. EVs have diverse biological activities, ranging from roles in development and …
cell type. EVs have diverse biological activities, ranging from roles in development and …
Overcoming TGFβ-mediated immune evasion in cancer
Transforming growth factor-β (TGFβ) signalling controls multiple cell fate decisions during
development and tissue homeostasis; hence, dysregulation of this pathway can drive …
development and tissue homeostasis; hence, dysregulation of this pathway can drive …
The evolving translational potential of small extracellular vesicles in cancer
Cancer-derived extracellular vesicles (EVs) are regarded as having promising potential to
be used as therapeutics and disease biomarkers. Mechanistically, EVs have been shown to …
be used as therapeutics and disease biomarkers. Mechanistically, EVs have been shown to …
Targeting cancer stem cell pathways for cancer therapy
L Yang, P Shi, G Zhao, J Xu, W Peng, J Zhang… - Signal transduction and …, 2020 - nature.com
Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication
M Mathieu, L Martin-Jaular, G Lavieu, C Théry - Nature cell biology, 2019 - nature.com
The ability of exosomes to transfer cargo from donor to acceptor cells, thereby triggering
phenotypic changes in the latter, has generated substantial interest in the scientific …
phenotypic changes in the latter, has generated substantial interest in the scientific …
Extracellular vesicles in cancer—implications for future improvements in cancer care
The sustained growth, invasion, and metastasis of cancer cells depend upon bidirectional
cell–cell communication within complex tissue environments. Such communication …
cell–cell communication within complex tissue environments. Such communication …
Current knowledge on exosome biogenesis and release
NP Hessvik, A Llorente - Cellular and Molecular Life Sciences, 2018 - Springer
Exosomes are nanosized membrane vesicles released by fusion of an organelle of the
endocytic pathway, the multivesicular body, with the plasma membrane. This process was …
endocytic pathway, the multivesicular body, with the plasma membrane. This process was …
Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance
The tumor microenvironment represents a complex network, in which tumor cells not only
communicate with each other but also with stromal and immune cells. Current research has …
communicate with each other but also with stromal and immune cells. Current research has …
[HTML][HTML] Biogenesis and function of extracellular vesicles in cancer
Extracellular vesicles (EVs) are heterogeneous multi-signal messengers that support cancer
growth and dissemination by mediating the tumor-stroma crosstalk. Exosomes are a subtype …
growth and dissemination by mediating the tumor-stroma crosstalk. Exosomes are a subtype …