[HTML][HTML] Comprehensive overview of Nrf2-related epigenetic regulations involved in ischemia-reperfusion injury
J Zhang, W Pan, Y Zhang, M Tan, Y Yin, Y Li… - Theranostics, 2022 - ncbi.nlm.nih.gov
Ischemic disease is a class of diseases in which an organ is ischemic due to vascular
occlusion, a major contributor to death and disability worldwide. However, when the blood …
occlusion, a major contributor to death and disability worldwide. However, when the blood …
NRF2 modulation in TRAMP mice: An in vivo model of prostate cancer
D Marzioni, R Mazzucchelli, S Fantone… - Molecular Biology …, 2023 - Springer
Abstract Background Prostate cancer (PCa) is one of the most common cancers worldwide
and oxidative stress is involved in its occurrence, development and progression. In fact, in …
and oxidative stress is involved in its occurrence, development and progression. In fact, in …
Natural bioactive compounds targeting epigenetic pathways in cancer: a review on alkaloids, terpenoids, quinones, and isothiocyanates
N El Omari, S Bakrim, M Bakha, JM Lorenzo… - Nutrients, 2021 - mdpi.com
Cancer is one of the most complex and systemic diseases affecting the health of mankind,
causing major deaths with a significant increase. This pathology is caused by several risk …
causing major deaths with a significant increase. This pathology is caused by several risk …
Epigenetic regulation of NRF2/KEAP1 by phytochemicals
S Bhattacharjee, RH Dashwood - Antioxidants, 2020 - mdpi.com
Epigenetics has provided a new dimension to our understanding of nuclear factor erythroid
2–related factor 2/Kelch-like ECH-associated protein 1 (human NRF2/KEAP1 and murine …
2–related factor 2/Kelch-like ECH-associated protein 1 (human NRF2/KEAP1 and murine …
[HTML][HTML] STAT3 signaling in ovarian cancer: a potential therapeutic target
R Liang, X Chen, L Chen, F Wan, K Chen, Y Sun… - Journal of …, 2020 - ncbi.nlm.nih.gov
Accumulating evidence has shown that Signal Transducer and Activator of Transcription 3
(STAT3) is thought to be a promising target for cancer therapy as STAT3 is frequently …
(STAT3) is thought to be a promising target for cancer therapy as STAT3 is frequently …
Corosolic acid and its structural analogs: A systematic review of their biological activities and underlying mechanism of action
XP Qian, XH Zhang, LN Sun, WF Xing, Y Wang… - Phytomedicine, 2021 - Elsevier
Background The corosolic acid (CA), also known as plant insulin, is a pentacyclic
triterpenoid extracted from plants such as Lagerstroemia speciosa. It has been shown to …
triterpenoid extracted from plants such as Lagerstroemia speciosa. It has been shown to …
[HTML][HTML] The role of natural products in targeting cardiovascular diseases via Nrf2 pathway: novel molecular mechanisms and therapeutic approaches
Cardiovascular diseases (CVDs) are closely linked to cellular oxidative stress and
inflammation. This may be resulted from the imbalance generation of reactive oxygen …
inflammation. This may be resulted from the imbalance generation of reactive oxygen …
The dietary flavone luteolin epigenetically activates the Nrf2 pathway and blocks cell transformation in human colorectal cancer HCT116 cells
Q Zuo, R Wu, X Xiao, C Yang, Y Yang… - Journal of Cellular …, 2018 - Wiley Online Library
Colorectal cancer remains a leading malignancy in humans. The importance of epigenetic
modification in the development of this disease is now being recognized. The reversible and …
modification in the development of this disease is now being recognized. The reversible and …
Epigenetic therapeutics targeting NRF2/KEAP1 signaling in cancer oxidative stress
S Zhang, S Duan, Z Xie, W Bao, B Xu… - Frontiers in …, 2022 - frontiersin.org
The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) and its negative
regulator kelch-like ECH-associated protein 1 (KEAP1) regulate various genes involved in …
regulator kelch-like ECH-associated protein 1 (KEAP1) regulate various genes involved in …
Epigenetics/epigenomics of triterpenoids in cancer prevention and in health
Triterpenoids are a powerful group of phytochemicals derived from plant foods and herbs.
Many reports have shown that they possess chemopreventive and chemotherapeutic effects …
Many reports have shown that they possess chemopreventive and chemotherapeutic effects …