In chronic lymphocytic leukemia (CLL), increasing knowledge of the biology of the tumor
cells has led to transformative improvements in our capacity to assess and treat patients …

The engagement of the B cell receptor (BcR) on the surface of leukemic cells represents a
key event in chronic lymphocytic leukemia (CLL) since it can lead to the maintenance and …

Chronic lymphocytic leukemia (CLL) is characterized by the existence of subsets of patients
with (quasi) identical, stereotyped B-cell receptor (BcR) immunoglobulins. Patients in certain …

Analyses of IGHV gene mutations in chronic lymphocytic leukemia (CLL) have had a major
impact on the prognostication and treatment of this disease. A hallmark of IGHV-mutation …

Sequence convergence, otherwise stereotypy, of B-cell receptor immunoglobulin (BcR IG)
from unrelated patients is a distinctive feature of the IG gene repertoire in chronic …

Highlights•Advances in BCR immunogenetics have led to key insights into CLL.•BCR
immunome analysis is widely applied to determine IGHV mutational status.•BCR stereotypy …

Chronic Lymphocytic Leukemia (CLL) is characterized by the accumulation of monoclonal
CD5+ B cells with low surface immunoglobulins (IG). About 40% of CLL clones utilize quasi …

Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by
the expansion of clonal cluster of differentiation (CD) 5+ CD19+ B cells in the blood, bone …

Introduction Several prognostic factors of chronic lymphocytic leukemia (CLL) have been
identified, such as cytogenetic aberrations and recurrent gene mutations. B-cell receptor …

Introduction The leukemic cells of patients with chronic lymphocytic leukemia (CLL) are often
unique, expressing remarkably similar IGHV-IGHD-IGHJ gene rearrangements,“stereotyped …