Attaining sufficient tissue exposure at the site of action to achieve the desired
pharmacodynamic effect on a target is an important determinant for any drug discovery …

Although recent regulatory approval of splice-switching oligonucleotides (SSOs) for the
treatment of neuromuscular disease such as Duchenne muscular dystrophy has been an …

The structure and thermal stability of complexes of RNA and DNA with phosphoryl guanidine
oligonucleotides (PGO) bearing modified phosphate residues in which 1, 3 …

Phosphoryl guanidine oligonucleotides (PGOs) are promising uncharged analogs of nucleic
acids and are used in a variety of applications. The importance of hydration is frequently …

Проведено исследование структуры и термической стабильности комплексов РНК и
ДНК с фосфорилгуанидиновыми олигонуклеотидами (ФГО), содержащими …