Biomarkers in hereditary angioedema
G Porebski, M Kwitniewski, A Reshef - Clinical Reviews in Allergy & …, 2021 - Springer
A biomarker is a defined characteristic measured as an indicator of normal, biologic,
pathogenic processes, or biological responses to an exposure or intervention. Diagnostic …
pathogenic processes, or biological responses to an exposure or intervention. Diagnostic …
Prevention of hereditary angioedema attacks with a subcutaneous C1 inhibitor
H Longhurst, M Cicardi, T Craig, K Bork… - New England journal …, 2017 - Mass Medical Soc
Background Hereditary angioedema is a disabling, potentially fatal condition caused by
deficiency (type I) or dysfunction (type II) of the C1 inhibitor protein. In a phase 2 trial, the use …
deficiency (type I) or dysfunction (type II) of the C1 inhibitor protein. In a phase 2 trial, the use …
“Nuts and bolts” of laboratory evaluation of angioedema
H Farkas, N Veszeli, E Kajdácsi, L Cervenak… - Clinical reviews in …, 2016 - Springer
Angioedema, as a distinct disease entity, often becomes a clinical challenge for physicians,
because it may cause a life-threatening condition, whereas prompt and accurate laboratory …
because it may cause a life-threatening condition, whereas prompt and accurate laboratory …
A focused parameter update: Hereditary angioedema, acquired C1 inhibitor deficiency, and angiotensin-converting enzyme inhibitor–associated angioedema
BL Zuraw, JA Bernstein, DM Lang, T Craig… - Journal of allergy and …, 2013 - Elsevier
These parameters were developed by the Joint Task Force on Practice Parameters (JTFPP),
representing the American Academy of Allergy, Asthma & Immunology (AAAAI); the …
representing the American Academy of Allergy, Asthma & Immunology (AAAAI); the …
Mutational spectrum and phenotypes in Danish families with hereditary angioedema because of C1 inhibitor deficiency
A Bygum, CR Fagerberg, D Ponard, N Monnier… - Allergy, 2011 - Wiley Online Library
To cite this article: Bygum A, Fagerberg CR, Ponard D, Monnier N, Lunardi J, Drouet C.
Mutational spectrum and phenotypes in Danish families with hereditary angioedema …
Mutational spectrum and phenotypes in Danish families with hereditary angioedema …
Cleavage of kininogen and subsequent bradykinin release by the complement component: mannose-binding lectin-associated serine protease (MASP)-1
Bradykinin (BK), generated from high-molecular-weight kininogen (HK) is the major
mediator of swelling attacks in hereditary angioedema (HAE), a disease associated with C1 …
mediator of swelling attacks in hereditary angioedema (HAE), a disease associated with C1 …
Recombinant human C1 esterase inhibitor for prophylaxis of hereditary angio-oedema: a phase 2, multicentre, randomised, double-blind, placebo-controlled …
MA Riedl, V Grivcheva-Panovska, D Moldovan, J Baker… - The Lancet, 2017 - thelancet.com
Background Hereditary angio-oedema is a recurrent, oedematous disorder caused by
deficiency of functional C1 inhibitor. Infusions of plasma-derived C1 esterase inhibitor deter …
deficiency of functional C1 inhibitor. Infusions of plasma-derived C1 esterase inhibitor deter …
Phase II study results of a replacement therapy for hereditary angioedema with subcutaneous C1‐inhibitor concentrate
Background Hereditary angioedema (HAE) due to C1 inhibitor deficiency manifests as
recurrent swelling attacks that can be disabling and sometimes fatal. Long‐term prophylaxis …
recurrent swelling attacks that can be disabling and sometimes fatal. Long‐term prophylaxis …
Applying complement therapeutics to rare diseases
ES Reis, DC Mastellos, D Yancopoulou, AM Risitano… - Clinical …, 2015 - Elsevier
Around 350 million people worldwide suffer from rare diseases. These may have a genetic,
infectious, or autoimmune basis, and several include an inflammatory component …
infectious, or autoimmune basis, and several include an inflammatory component …
Hereditary angioedema caused by C1-esterase inhibitor deficiency: a literature-based analysis and clinical commentary on prophylaxis treatment strategies
RG Gower, PJ Busse, E Aygören-Pürsün… - World Allergy …, 2011 - Springer
Hereditary angioedema (HAE) caused by C1-esterase inhibitor deficiency is an autosomal-
dominant disease resulting from a mutation in the C1-inhibitor gene. HAE is characterized …
dominant disease resulting from a mutation in the C1-inhibitor gene. HAE is characterized …