[HTML][HTML] Mechanisms of long COVID and the path toward therapeutics

MJ Peluso, SG Deeks - Cell, 2024 - cell.com
Long COVID, a type of post-acute sequelae of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2)(PASC) defined by medically unexplained symptoms following …

Neutrophil extracellular traps and long COVID

A Shafqat, MH Omer, I Albalkhi… - Frontiers in …, 2023 - frontiersin.org
Post-acute COVID-19 sequelae, commonly known as long COVID, encompasses a range of
systemic symptoms experienced by a significant number of COVID-19 survivors. The …

Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment

C Greene, R Connolly, D Brennan, A Laffan… - Nature …, 2024 - nature.com
Vascular disruption has been implicated in coronavirus disease 2019 (COVID-19)
pathogenesis and may predispose to the neurological sequelae associated with long …

[HTML][HTML] Fibrin drives thromboinflammation and neuropathology in COVID-19

JK Ryu, Z Yan, M Montano, EG Sozmen, K Dixit… - Nature, 2024 - nature.com
Life-threatening thrombotic events and neurological symptoms are prevalent in COVID-19
and are persistent in patients with long COVID experiencing post-acute sequelae of SARS …

[HTML][HTML] Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK

M Taquet, Z Skorniewska, T De Deyn… - The Lancet …, 2024 - thelancet.com
Background COVID-19 is known to be associated with increased risks of cognitive and
psychiatric outcomes after the acute phase of disease. We aimed to assess whether these …

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

F Liew, C Efstathiou, S Fontanella, M Richardson… - Nature …, 2024 - nature.com
One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged
symptoms termed long coronavirus disease (COVID), yet disease phenotypes and …

Post-hospitalisation COVID-19 cognitive deficits at one year are global and associated with elevated brain injury markers and grey matter volume reduction

GK Wood, BF Sargent, ZUA Ahmad, K Tharmaratnam… - Nature medicine, 2024 - nature.com
The spectrum, pathophysiology, and recovery trajectory of persistent post-COVID-19
cognitive deficits are unknown, limiting our ability to develop prevention and treatment …

Sepsis-trained macrophages promote antitumoral tissue-resident T cells

A Broquet, V Gourain, T Goronflot, V Le Mabecque… - Nature …, 2024 - nature.com
Sepsis induces immune alterations, which last for months after the resolution of illness. The
effect of this immunological reprogramming on the risk of developing cancer is unclear. Here …

Brain and cognitive changes in patients with long COVID compared with infection-recovered control subjects

VM Serrano del Pueblo, G Serrano-Heras… - Brain, 2024 - academic.oup.com
Abstract Between 2.5% and 28% of people infected with SARS-CoV-2 suffer long COVID or
persistence of symptoms for months after acute illness. Many symptoms are neurological …

Early biological markers of post-acute sequelae of SARS-CoV-2 infection

S Lu, MJ Peluso, DV Glidden, MC Davidson… - Nature …, 2024 - nature.com
To understand the roles of acute-phase viral dynamics and host immune responses in post-
acute sequelae of SARS-CoV-2 infection (PASC), we enrolled 136 participants within 5 days …